| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 17 | 17 | 8 | 6 | 5.20 | .312 | 1.35 | 9.2 | 2.9 | 7.1 | 116.0 | 119 | 69 | 67 | 16 | 38 | 91 | 3 | 0 | 0 | 0 | 6 | 1 | 3 | 4.23 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 16 | 16 | 8 | 6 | 5.57 | .308 | 1.30 | 9.3 | 2.4 | 5.7 | 105.0 | 108 | 65 | 65 | 17 | 28 | 66 | 1 | 0 | 0 | 0 | 6 | 4 | 2 | 4.76 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 41 | 0 | 2 | 8 | 5.31 | .342 | 1.56 | 9.2 | 4.9 | 8.8 | 42.1 | 43 | 25 | 25 | 7 | 23 | 41 | 0 | 21 | 4 | 0 | 0 | 0 | 4 | 4.86 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 29 | 0 | 1 | 1 | 4.85 | .355 | 1.62 | 11.5 | 3.4 | 9.0 | 29.2 | 37 | 17 | 16 | 8 | 11 | 29 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 5.83 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 46 | 0 | 4 | 0 | 6.57 | .374 | 1.74 | 11.2 | 4.7 | 7.7 | 50.2 | 62 | 37 | 37 | 9 | 26 | 43 | 0 | 3 | 1 | 0 | 0 | 3 | 0 | 5.36 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 32 | 0 | 2 | 2 | 5.91 | .351 | 1.63 | 9.3 | 5.3 | 6.5 | 32.0 | 33 | 24 | 21 | 5 | 19 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 5.38 |