| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 18 | 18 | 4 | 4 | 4.01 | .294 | 1.22 | 8.3 | 2.7 | 10.5 | 114.1 | 105 | 55 | 51 | 14 | 34 | 133 | 1 | 0 | 0 | 0 | 9 | 4 | 0 | 3.26 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 17 | 17 | 4 | 10 | 5.62 | .337 | 1.49 | 10.7 | 2.9 | 8.6 | 97.2 | 115 | 68 | 61 | 15 | 31 | 93 | 0 | 0 | 0 | 0 | 7 | 3 | 5 | 4.14 |
| SP | Alexander, P.Alexander, Pete # >> | 28 | 1915 | R | 88 | 17 | 17 | 9 | 6 | 3.99 | .286 | 1.18 | 8.3 | 2.4 | 5.4 | 121.2 | 112 | 58 | 54 | 12 | 32 | 72 | 4 | 0 | 0 | 1 | 11 | 2 | 0 | 3.94 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 17 | 17 | 8 | 3 | 4.33 | .314 | 1.33 | 8.0 | 3.9 | 7.4 | 104.0 | 93 | 56 | 50 | 16 | 45 | 85 | 0 | 0 | 0 | 0 | 9 | 5 | 1 | 4.81 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 16 | 16 | 3 | 5 | 5.00 | .370 | 1.74 | 9.9 | 5.9 | 8.0 | 93.2 | 102 | 58 | 52 | 8 | 61 | 83 | 1 | 0 | 0 | 0 | 5 | 2 | 0 | 4.37 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 26 | 0 | 2 | 1 | 3.16 | .280 | 1.17 | 6.5 | 4.3 | 10.1 | 25.2 | 18 | 11 | 9 | 2 | 12 | 28 | 0 | 18 | 5 | 0 | 0 | 0 | 0 | 3.24 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 35 | 0 | 3 | 3 | 1.74 | .266 | 1.09 | 5.5 | 4.4 | 9.0 | 41.1 | 25 | 9 | 8 | 1 | 20 | 41 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.78 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 41 | 0 | 2 | 4 | 4.27 | .327 | 1.42 | 9.0 | 3.8 | 7.3 | 59.0 | 59 | 32 | 28 | 4 | 25 | 48 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 3.63 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 36 | 0 | 3 | 5 | 7.57 | .412 | 2.07 | 11.3 | 7.7 | 8.7 | 35.2 | 44 | 31 | 30 | 7 | 30 | 34 | 0 | 0 | 3 | 0 | 0 | 1 | 2 | 6.31 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 32 | 0 | 1 | 2 | 3.55 | .349 | 1.55 | 9.3 | 4.6 | 10.4 | 33.0 | 34 | 13 | 13 | 2 | 17 | 38 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.21 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 19 | 0 | 2 | 0 | 1.80 | .265 | 1.08 | 7.6 | 2.2 | 7.2 | 25.0 | 21 | 6 | 5 | 2 | 6 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.16 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 14 | 0 | 1 | 0 | 0.98 | .191 | 0.71 | 4.5 | 2.0 | 7.0 | 18.1 | 9 | 2 | 2 | 1 | 4 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.83 |