| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 37 | 37 | 17 | 13 | 3.22 | .280 | 1.12 | 6.8 | 3.3 | 8.1 | 273.2 | 206 | 105 | 98 | 21 | 101 | 245 | 10 | 0 | 0 | 1 | 26 | 13 | 4 | 3.46 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 36 | 36 | 11 | 19 | 3.92 | .285 | 1.19 | 8.5 | 2.2 | 5.4 | 266.1 | 252 | 122 | 116 | 31 | 64 | 161 | 13 | 0 | 0 | 2 | 20 | 3 | 5 | 4.06 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 34 | 34 | 13 | 12 | 4.39 | .300 | 1.26 | 8.5 | 2.9 | 7.7 | 233.2 | 220 | 125 | 114 | 31 | 74 | 199 | 3 | 0 | 0 | 1 | 16 | 6 | 5 | 4.05 |
| SP | Pfiester, J.Pfiester, Jack † >> | 28 | 1906 | L | 74 | 34 | 34 | 21 | 10 | 3.40 | .281 | 1.17 | 7.1 | 3.4 | 4.8 | 264.1 | 208 | 105 | 100 | 23 | 100 | 140 | 8 | 0 | 0 | 1 | 23 | 2 | 2 | 4.23 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 73 | 0 | 4 | 3 | 3.34 | .238 | 0.92 | 3.9 | 4.5 | 11.1 | 56.2 | 24 | 23 | 21 | 4 | 28 | 69 | 0 | 2 | 0 | 0 | 0 | 1 | 6 | 3.02 |
| RP | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 44 | 58 | 0 | 2 | 1 | 3.18 | .265 | 1.03 | 6.0 | 3.5 | 4.6 | 39.2 | 26 | 14 | 14 | 0 | 15 | 20 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 3.28 |
| CL | Hoffman, T.Hoffman, Trevor † >> | 31 | 1998 | R | 76 | 58 | 0 | 2 | 2 | 3.69 | .275 | 1.10 | 7.1 | 2.9 | 9.3 | 53.2 | 42 | 23 | 22 | 5 | 17 | 55 | 0 | 49 | 4 | 0 | 0 | 2 | 6 | 3.23 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 30 | 0 | 3 | 0 | 2.43 | .252 | 1.01 | 5.9 | 3.4 | 7.4 | 29.2 | 19 | 8 | 8 | 1 | 11 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.93 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 30 | 0 | 4 | 3 | 3.79 | .314 | 1.37 | 7.2 | 5.4 | 8.7 | 35.2 | 28 | 15 | 15 | 3 | 21 | 34 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 3.97 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 65 | 60 | 0 | 0 | 1 | 3.65 | .307 | 1.31 | 8.6 | 3.3 | 8.2 | 44.1 | 42 | 19 | 18 | 6 | 16 | 40 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 4.11 |