| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 84 | 34 | 34 | 16 | 12 | 3.83 | .280 | 1.16 | 8.4 | 2.1 | 5.6 | 240.0 | 224 | 103 | 102 | 24 | 55 | 148 | 9 | 0 | 0 | 4 | 18 | 1 | 1 | 3.77 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 33 | 33 | 15 | 11 | 3.98 | .300 | 1.26 | 8.0 | 3.4 | 5.9 | 226.1 | 201 | 106 | 100 | 22 | 85 | 148 | 8 | 0 | 0 | 2 | 18 | 5 | 5 | 4.15 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 30 | 30 | 9 | 9 | 5.66 | .347 | 1.58 | 9.7 | 4.6 | 6.0 | 178.0 | 191 | 116 | 112 | 25 | 91 | 118 | 0 | 0 | 0 | 0 | 13 | 2 | 8 | 5.07 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 86 | 0 | 9 | 5 | 2.87 | .287 | 1.18 | 6.4 | 4.2 | 8.9 | 122.1 | 87 | 43 | 39 | 10 | 57 | 120 | 0 | 12 | 4 | 0 | 0 | 4 | 0 | 3.60 |
| RP | Benitez, A.Benitez, Armando # >> | 32 | 2004 | R | 82 | 71 | 0 | 3 | 6 | 4.21 | .289 | 1.21 | 7.7 | 3.1 | 5.0 | 92.0 | 79 | 43 | 43 | 12 | 32 | 51 | 0 | 10 | 5 | 0 | 0 | 1 | 0 | 4.66 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 55 | 0 | 4 | 5 | 3.43 | .294 | 1.25 | 8.4 | 2.9 | 10.4 | 65.2 | 61 | 30 | 25 | 4 | 21 | 75 | 0 | 6 | 5 | 0 | 0 | 0 | 0 | 2.46 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 50 | 0 | 6 | 4 | 2.26 | .313 | 1.35 | 6.0 | 6.2 | 5.8 | 87.2 | 58 | 30 | 22 | 9 | 60 | 56 | 0 | 5 | 0 | 0 | 0 | 2 | 4 | 5.20 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 60 | 13 | 1 | 2 | 1 | 4.32 | .306 | 1.32 | 9.8 | 2.2 | 4.4 | 33.1 | 36 | 16 | 16 | 6 | 8 | 16 | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 5.12 |