| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 8 | 8 | 3 | 1 | 5.23 | .351 | 1.61 | 11.8 | 2.8 | 6.9 | 51.2 | 67 | 36 | 30 | 9 | 16 | 39 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.76 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 78 | 8 | 8 | 3 | 2 | 3.52 | .284 | 1.16 | 7.5 | 3.1 | 8.8 | 53.2 | 44 | 22 | 21 | 6 | 18 | 52 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 3.64 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 62 | 7 | 7 | 5 | 1 | 3.63 | .288 | 1.21 | 6.6 | 4.3 | 3.8 | 52.0 | 38 | 21 | 21 | 8 | 25 | 22 | 2 | 0 | 0 | 1 | 4 | 0 | 0 | 5.60 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 14 | 0 | 1 | 2 | 6.57 | .327 | 1.46 | 10.5 | 3.0 | 13.5 | 12.1 | 14 | 9 | 9 | 4 | 4 | 18 | 0 | 10 | 3 | 0 | 0 | 0 | 0 | 5.33 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 13 | 0 | 1 | 1 | 6.00 | .286 | 1.20 | 6.6 | 4.2 | 8.4 | 15.0 | 11 | 10 | 10 | 4 | 7 | 14 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 6.00 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 22 | 0 | 1 | 1 | 2.61 | .262 | 1.06 | 9.5 | 0.5 | 8.1 | 20.2 | 21 | 6 | 6 | 4 | 1 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 12 | 0 | 1 | 1 | 3.07 | .290 | 1.23 | 7.1 | 4.5 | 9.0 | 14.2 | 11 | 5 | 5 | 2 | 7 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.36 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 3 | 0 | 1 | 0 | 1.93 | .176 | 0.64 | 2.3 | 4.5 | 9.0 | 4.2 | 1 | 1 | 1 | 1 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.75 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 2 | 0 | 1 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 18.0 | 2.1 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1.00 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McDowell, S.McDowell, Sam >> | 26 | 1968 | L | 46 | 1 | 0 | 0 | 1 | 4.91 | .389 | 1.91 | 15.0 | 6.0 | 9.0 | 3.2 | 5 | 5 | 2 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |