| SP | Johnson, W.Johnson, Walter † >> | 26 | 1913 | R | 95 | 20 | 20 | 11 | 6 | 3.26 | .258 | 1.03 | 7.4 | 1.9 | 4.8 | 151.2 | 124 | 61 | 55 | 10 | 32 | 80 | 5 | 0 | 0 | 3 | 10 | 2 | 3 | 3.48 |
| SP | Richard, J.Richard, J.R. † >> | 30 | 1980 | R | 90 | 19 | 19 | 12 | 4 | 3.23 | .316 | 1.37 | 8.5 | 3.9 | 8.4 | 125.1 | 118 | 51 | 45 | 11 | 54 | 116 | 0 | 0 | 0 | 0 | 14 | 2 | 2 | 3.63 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 18 | 18 | 8 | 3 | 4.42 | .335 | 1.49 | 8.2 | 5.3 | 8.6 | 108.0 | 98 | 57 | 53 | 15 | 63 | 103 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 4.70 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 30 | 0 | 1 | 1 | 3.26 | .266 | 1.05 | 6.0 | 3.6 | 9.9 | 30.1 | 20 | 12 | 11 | 3 | 12 | 33 | 0 | 19 | 1 | 0 | 0 | 1 | 0 | 3.40 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 40 | 0 | 0 | 2 | 4.32 | .302 | 1.30 | 7.2 | 4.6 | 9.7 | 41.2 | 33 | 20 | 20 | 5 | 21 | 44 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 3.98 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 40 | 0 | 2 | 3 | 3.02 | .243 | 0.94 | 7.6 | 1.0 | 6.8 | 44.2 | 37 | 16 | 15 | 2 | 5 | 33 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 2.50 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 26 | 0 | 2 | 2 | 3.90 | .366 | 1.66 | 9.0 | 6.3 | 6.7 | 27.2 | 27 | 13 | 12 | 1 | 19 | 20 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.33 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 20 | 0 | 2 | 1 | 0.81 | .256 | 1.03 | 5.7 | 3.7 | 9.8 | 22.1 | 14 | 6 | 2 | 2 | 9 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.23 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 25 | 0 | 3 | 2 | 3.41 | .317 | 1.39 | 9.0 | 3.8 | 5.2 | 31.2 | 31 | 13 | 12 | 3 | 13 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.35 |