| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 29 | 29 | 12 | 10 | 4.62 | .323 | 1.41 | 8.2 | 4.5 | 5.8 | 169.1 | 154 | 91 | 87 | 20 | 84 | 108 | 0 | 0 | 0 | 0 | 13 | 4 | 3 | 4.82 |
| SP | Johnson, R.Johnson, Randy † >> | 41 | 2004 | L | 84 | 28 | 28 | 12 | 7 | 4.93 | .304 | 1.28 | 9.1 | 2.6 | 7.4 | 169.2 | 170 | 94 | 93 | 30 | 48 | 139 | 4 | 0 | 0 | 1 | 15 | 4 | 1 | 4.59 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 28 | 28 | 8 | 15 | 5.31 | .319 | 1.38 | 9.5 | 3.0 | 4.9 | 190.0 | 200 | 125 | 112 | 33 | 63 | 104 | 5 | 0 | 0 | 1 | 11 | 4 | 6 | 5.22 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 57 | 0 | 5 | 5 | 3.19 | .293 | 1.23 | 6.4 | 4.6 | 10.2 | 62.0 | 44 | 22 | 22 | 7 | 32 | 70 | 0 | 33 | 5 | 0 | 0 | 1 | 0 | 3.81 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 51 | 0 | 2 | 2 | 2.88 | .275 | 1.14 | 8.2 | 2.1 | 9.6 | 56.1 | 51 | 19 | 18 | 6 | 13 | 60 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 2.95 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 53 | 0 | 4 | 2 | 4.58 | .332 | 1.49 | 9.2 | 4.2 | 7.8 | 53.0 | 54 | 29 | 27 | 4 | 25 | 46 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.66 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 65 | 65 | 0 | 4 | 0 | 4.06 | .288 | 1.20 | 7.4 | 3.4 | 8.5 | 51.0 | 42 | 23 | 23 | 5 | 19 | 48 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.57 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 42 | 41 | 0 | 3 | 2 | 5.48 | .354 | 1.65 | 9.4 | 5.5 | 7.4 | 44.1 | 46 | 29 | 27 | 10 | 27 | 36 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 6.16 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 35 | 0 | 3 | 3 | 2.77 | .291 | 1.23 | 8.5 | 2.5 | 6.9 | 39.0 | 37 | 12 | 12 | 6 | 11 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 34 | 0 | 1 | 0 | 3.21 | .276 | 1.12 | 4.5 | 5.6 | 7.7 | 42.0 | 21 | 16 | 15 | 3 | 26 | 36 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.14 |