| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 30 | 30 | 15 | 8 | 3.26 | .276 | 1.13 | 7.4 | 2.7 | 8.3 | 226.2 | 187 | 87 | 82 | 29 | 69 | 208 | 9 | 0 | 0 | 3 | 21 | 3 | 6 | 3.78 |
| SP | Santana, J.Santana, Johan † # >> | 25 | 2004 | L | 86 | 29 | 29 | 16 | 4 | 3.28 | .271 | 1.08 | 6.8 | 2.9 | 8.0 | 197.2 | 149 | 75 | 72 | 23 | 64 | 175 | 2 | 0 | 0 | 1 | 22 | 7 | 3 | 3.82 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 28 | 28 | 12 | 6 | 4.30 | .315 | 1.35 | 10.3 | 1.9 | 5.5 | 188.1 | 215 | 98 | 90 | 17 | 40 | 115 | 2 | 0 | 0 | 0 | 15 | 5 | 1 | 3.67 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 70 | 27 | 27 | 6 | 14 | 5.89 | .346 | 1.58 | 10.7 | 3.5 | 7.1 | 166.2 | 198 | 115 | 109 | 20 | 65 | 131 | 1 | 0 | 0 | 0 | 9 | 2 | 2 | 4.20 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 62 | 0 | 6 | 10 | 2.43 | .235 | 0.92 | 5.6 | 2.7 | 10.3 | 63.0 | 39 | 18 | 17 | 5 | 19 | 72 | 0 | 32 | 4 | 0 | 0 | 0 | 1 | 2.65 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 56 | 0 | 1 | 5 | 3.77 | .274 | 1.13 | 7.4 | 2.8 | 9.2 | 57.1 | 47 | 26 | 24 | 10 | 18 | 58 | 0 | 6 | 7 | 0 | 0 | 0 | 0 | 4.19 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 66 | 0 | 10 | 0 | 3.84 | .287 | 1.21 | 7.6 | 3.3 | 8.6 | 70.1 | 59 | 31 | 30 | 10 | 26 | 67 | 0 | 2 | 4 | 0 | 0 | 0 | 4 | 4.06 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 41 | 0 | 2 | 3 | 3.04 | .274 | 1.11 | 6.8 | 3.2 | 9.5 | 50.1 | 38 | 19 | 17 | 2 | 18 | 53 | 0 | 0 | 1 | 0 | 0 | 1 | 6 | 2.54 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 6 | 0 | 2 | 0 | 4.05 | .286 | 1.20 | 9.0 | 3.0 | 6.0 | 6.2 | 6 | 3 | 3 | 1 | 2 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.83 |