| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 34 | 34 | 13 | 15 | 3.98 | .279 | 1.14 | 7.5 | 2.7 | 8.4 | 253.1 | 212 | 114 | 112 | 34 | 77 | 237 | 13 | 0 | 0 | 2 | 18 | 5 | 5 | 3.85 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 33 | 33 | 11 | 13 | 4.13 | .276 | 1.13 | 8.6 | 1.6 | 8.6 | 233.1 | 223 | 117 | 107 | 36 | 41 | 223 | 6 | 0 | 0 | 0 | 16 | 3 | 3 | 3.66 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 68 | 31 | 31 | 14 | 9 | 5.85 | .332 | 1.48 | 10.0 | 3.4 | 8.4 | 189.1 | 210 | 124 | 123 | 33 | 71 | 177 | 1 | 0 | 0 | 0 | 12 | 1 | 4 | 4.54 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 90 | 0 | 4 | 6 | 3.31 | .266 | 1.07 | 6.4 | 3.3 | 8.8 | 133.1 | 94 | 51 | 49 | 13 | 49 | 130 | 0 | 15 | 6 | 0 | 0 | 2 | 0 | 3.47 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 65 | 0 | 3 | 2 | 3.45 | .251 | 1.00 | 7.2 | 1.9 | 10.0 | 75.2 | 60 | 29 | 29 | 12 | 16 | 83 | 0 | 9 | 0 | 0 | 0 | 0 | 5 | 3.51 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 56 | 42 | 0 | 3 | 3 | 7.54 | .373 | 1.76 | 11.6 | 4.4 | 7.0 | 45.1 | 58 | 39 | 38 | 6 | 22 | 35 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 4.71 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 2 | 0 | 1 | 0 | 0.00 | .176 | 0.64 | 4.5 | 2.3 | 2.3 | 4.2 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.25 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 48 | 23 | 0 | 2 | 2 | 5.01 | .349 | 1.58 | 8.7 | 5.6 | 9.0 | 32.1 | 31 | 19 | 18 | 4 | 20 | 32 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 4.59 |