| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 30 | 30 | 13 | 12 | 4.12 | .303 | 1.27 | 8.6 | 2.8 | 8.0 | 188.0 | 180 | 90 | 86 | 21 | 59 | 168 | 2 | 0 | 0 | 1 | 17 | 6 | 0 | 3.70 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 27 | 27 | 13 | 9 | 3.57 | .301 | 1.27 | 8.4 | 3.1 | 4.1 | 201.2 | 188 | 91 | 80 | 20 | 69 | 91 | 4 | 0 | 0 | 1 | 15 | 3 | 2 | 4.46 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 27 | 27 | 8 | 12 | 6.18 | .361 | 1.67 | 9.8 | 5.2 | 7.1 | 150.0 | 164 | 108 | 103 | 29 | 87 | 118 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 5.74 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 53 | 0 | 2 | 6 | 1.91 | .249 | 0.96 | 5.8 | 3.0 | 9.1 | 61.1 | 39 | 14 | 13 | 2 | 20 | 62 | 0 | 32 | 4 | 0 | 0 | 2 | 1 | 2.48 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 80 | 0 | 2 | 2 | 3.70 | .311 | 1.34 | 6.8 | 5.3 | 6.4 | 56.0 | 42 | 23 | 23 | 7 | 33 | 40 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 5.02 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 52 | 0 | 3 | 3 | 4.54 | .318 | 1.40 | 8.2 | 4.6 | 7.4 | 33.2 | 30 | 18 | 17 | 3 | 17 | 27 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 4.09 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 75 | 0 | 1 | 0 | 3.28 | .286 | 1.16 | 7.0 | 3.5 | 8.8 | 46.2 | 36 | 17 | 17 | 3 | 18 | 45 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.20 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 28 | 0 | 3 | 1 | 3.60 | .299 | 1.20 | 7.6 | 3.2 | 8.6 | 25.0 | 21 | 10 | 10 | 4 | 9 | 24 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.48 |