| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 25 | 25 | 10 | 12 | 3.77 | .275 | 1.11 | 7.7 | 2.3 | 7.9 | 181.1 | 155 | 85 | 76 | 23 | 47 | 158 | 3 | 0 | 0 | 2 | 13 | 4 | 4 | 3.75 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 72 | 24 | 24 | 8 | 12 | 4.19 | .301 | 1.26 | 7.9 | 3.4 | 7.8 | 152.2 | 134 | 74 | 71 | 22 | 58 | 132 | 0 | 0 | 0 | 0 | 14 | 5 | 6 | 4.39 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 63 | 23 | 23 | 10 | 6 | 4.59 | .299 | 1.25 | 8.6 | 2.7 | 7.5 | 157.0 | 150 | 81 | 80 | 18 | 47 | 131 | 3 | 0 | 0 | 0 | 12 | 4 | 1 | 3.80 |
| SP | Valenzuela, F.Valenzuela, Fernando # >> | 21 | 1981 | L | 61 | 24 | 24 | 5 | 9 | 5.34 | .333 | 1.46 | 9.5 | 3.6 | 6.8 | 167.0 | 177 | 104 | 99 | 39 | 66 | 126 | 4 | 0 | 0 | 0 | 8 | 7 | 4 | 5.84 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 67 | 0 | 2 | 6 | 3.47 | .254 | 1.01 | 5.6 | 3.5 | 8.7 | 96.0 | 60 | 38 | 37 | 13 | 37 | 93 | 0 | 4 | 6 | 0 | 0 | 1 | 0 | 4.01 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 57 | 0 | 1 | 4 | 3.41 | .297 | 1.27 | 7.7 | 3.8 | 8.2 | 68.2 | 58 | 26 | 26 | 11 | 29 | 62 | 0 | 4 | 4 | 0 | 0 | 0 | 11 | 4.56 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 42 | 0 | 6 | 2 | 2.37 | .285 | 1.18 | 6.8 | 3.9 | 9.2 | 49.1 | 37 | 15 | 13 | 4 | 21 | 50 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 3.37 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 55 | 32 | 0 | 2 | 2 | 3.58 | .338 | 1.50 | 8.7 | 5.1 | 6.5 | 32.2 | 31 | 13 | 13 | 1 | 18 | 23 | 0 | 2 | 1 | 0 | 0 | 1 | 4 | 3.75 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 57 | 2 | 0 | 0 | 1 | 5.68 | .387 | 1.89 | 10.5 | 7.5 | 15.0 | 6.1 | 7 | 4 | 4 | 1 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.33 |