| SP | Scott, M.Scott, Mike # >> | 31 | 1986 | R | 92 | 26 | 26 | 12 | 8 | 4.85 | .303 | 1.27 | 8.4 | 3.0 | 7.9 | 163.1 | 153 | 89 | 88 | 32 | 55 | 143 | 3 | 0 | 0 | 2 | 13 | 5 | 1 | 4.90 |
| SP | Johnson, R.Johnson, Randy † >> | 41 | 2004 | L | 90 | 24 | 24 | 17 | 4 | 3.10 | .268 | 1.08 | 7.0 | 2.7 | 8.6 | 182.2 | 142 | 63 | 63 | 27 | 55 | 174 | 8 | 0 | 0 | 0 | 17 | 4 | 1 | 3.99 |
| SP | Ryan, N.Ryan, Nolan † $ >> | 44 | 1991 | R | 80 | 24 | 24 | 10 | 8 | 3.07 | .275 | 1.12 | 6.0 | 4.1 | 8.6 | 164.1 | 109 | 61 | 56 | 16 | 75 | 157 | 1 | 0 | 0 | 0 | 17 | 3 | 8 | 3.78 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 23 | 23 | 11 | 6 | 3.84 | .293 | 1.19 | 8.4 | 2.4 | 6.0 | 159.1 | 148 | 75 | 68 | 23 | 42 | 106 | 2 | 0 | 0 | 1 | 15 | 8 | 2 | 4.49 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 62 | 0 | 6 | 2 | 2.33 | .237 | 0.89 | 5.1 | 3.0 | 9.3 | 69.2 | 39 | 20 | 18 | 4 | 23 | 71 | 0 | 11 | 1 | 0 | 0 | 3 | 0 | 2.83 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 47 | 0 | 4 | 1 | 2.62 | .276 | 1.13 | 5.6 | 4.6 | 9.3 | 55.0 | 34 | 16 | 16 | 7 | 28 | 57 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 4.16 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 32 | 0 | 0 | 1 | 2.19 | .265 | 1.08 | 5.8 | 3.9 | 11.2 | 37.0 | 24 | 10 | 9 | 5 | 16 | 46 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.57 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 64 | 24 | 0 | 3 | 2 | 3.80 | .304 | 1.27 | 9.0 | 2.7 | 7.8 | 23.2 | 23 | 10 | 10 | 4 | 7 | 20 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.57 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 93 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 11 | 0 | 4 | 2 | 4.05 | .286 | 1.20 | 7.6 | 3.5 | 12.5 | 13.1 | 11 | 6 | 6 | 2 | 5 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 74 | 0 | 1 | 0 | 2.25 | .204 | 0.75 | 4.2 | 2.6 | 10.3 | 56.0 | 26 | 14 | 14 | 4 | 16 | 64 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 2.55 |