| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 21 | 21 | 11 | 3 | 2.47 | .242 | 0.93 | 6.6 | 1.8 | 10.1 | 142.1 | 104 | 41 | 39 | 21 | 29 | 159 | 0 | 0 | 0 | 0 | 17 | 3 | 0 | 3.36 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 20 | 20 | 10 | 6 | 3.31 | .269 | 1.10 | 6.9 | 3.0 | 9.3 | 138.2 | 106 | 53 | 51 | 14 | 46 | 143 | 1 | 0 | 0 | 0 | 13 | 1 | 1 | 3.27 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 20 | 20 | 8 | 6 | 3.12 | .276 | 1.10 | 6.4 | 3.5 | 7.7 | 127.0 | 90 | 49 | 44 | 13 | 50 | 109 | 0 | 0 | 0 | 0 | 15 | 5 | 2 | 3.91 |
| SP | Tanana, F.Tanana, Frank # >> | 23 | 1976 | L | 74 | 20 | 20 | 9 | 9 | 4.03 | .285 | 1.15 | 8.0 | 2.3 | 6.7 | 143.0 | 127 | 68 | 64 | 21 | 37 | 106 | 8 | 0 | 0 | 2 | 12 | 7 | 1 | 4.35 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 18 | 18 | 8 | 6 | 4.88 | .299 | 1.25 | 8.8 | 2.5 | 6.4 | 118.0 | 115 | 67 | 64 | 20 | 33 | 84 | 4 | 0 | 0 | 1 | 7 | 3 | 2 | 4.69 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 57 | 0 | 3 | 0 | 2.20 | .250 | 1.00 | 7.3 | 1.7 | 8.1 | 49.0 | 40 | 12 | 12 | 4 | 9 | 44 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.82 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 45 | 0 | 7 | 4 | 2.54 | .266 | 1.07 | 6.8 | 2.7 | 8.2 | 46.0 | 35 | 14 | 13 | 4 | 14 | 42 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 3.28 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 24 | 0 | 2 | 1 | 2.35 | .207 | 0.72 | 6.0 | 0.6 | 7.2 | 15.1 | 10 | 4 | 4 | 1 | 1 | 12 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.67 |
| CL | Chapman, A.Chapman, Aroldis $ >> | 37 | 2025 | L | 96 | 30 | 0 | 1 | 2 | 3.52 | .287 | 1.21 | 6.6 | 4.5 | 10.2 | 30.2 | 22 | 12 | 12 | 3 | 15 | 34 | 0 | 24 | 2 | 0 | 0 | 0 | 0 | 3.53 |