| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 8 | 1 | 3.04 | .304 | 1.29 | 7.6 | 4.0 | 9.5 | 83.0 | 70 | 31 | 28 | 10 | 37 | 88 | 0 | 0 | 0 | 0 | 9 | 2 | 0 | 3.86 |
| SP | Cole, G.Cole, Gerrit $ >> | 28 | 2019 | R | 92 | 13 | 13 | 4 | 8 | 5.36 | .316 | 1.34 | 9.2 | 2.9 | 8.7 | 82.1 | 84 | 51 | 49 | 12 | 26 | 79 | 1 | 0 | 0 | 0 | 5 | 4 | 1 | 4.07 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 12 | 12 | 4 | 5 | 3.80 | .299 | 1.24 | 8.2 | 2.9 | 7.4 | 83.0 | 76 | 38 | 35 | 12 | 27 | 68 | 1 | 0 | 0 | 0 | 8 | 3 | 0 | 4.33 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 12 | 12 | 4 | 7 | 6.82 | .349 | 1.59 | 11.0 | 3.3 | 6.3 | 66.0 | 81 | 50 | 50 | 15 | 24 | 46 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 5.70 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 12 | 12 | 5 | 6 | 5.25 | .343 | 1.54 | 10.2 | 3.7 | 5.2 | 82.1 | 93 | 50 | 48 | 6 | 34 | 47 | 2 | 0 | 0 | 1 | 2 | 2 | 3 | 4.12 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 25 | 0 | 0 | 3 | 5.09 | .324 | 1.39 | 8.6 | 3.9 | 10.6 | 23.0 | 22 | 13 | 13 | 6 | 10 | 27 | 0 | 18 | 2 | 0 | 0 | 1 | 2 | 5.48 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 29 | 0 | 2 | 0 | 2.49 | .193 | 0.69 | 3.6 | 2.7 | 8.8 | 43.1 | 17 | 12 | 12 | 3 | 13 | 42 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.93 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 27 | 0 | 2 | 1 | 5.54 | .345 | 1.54 | 9.7 | 4.2 | 5.5 | 26.0 | 28 | 17 | 16 | 4 | 12 | 16 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.27 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 76 | 23 | 0 | 0 | 2 | 5.06 | .316 | 1.39 | 9.7 | 3.1 | 6.2 | 26.2 | 28 | 15 | 15 | 4 | 9 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.65 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 5 | 0 | 0 | 0 | 0.00 | .138 | 0.48 | 2.3 | 2.3 | 3.4 | 8.1 | 2 | 0 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |