| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 32 | 32 | 10 | 15 | 4.12 | .293 | 1.23 | 8.1 | 3.0 | 10.8 | 205.1 | 185 | 101 | 94 | 31 | 68 | 245 | 2 | 0 | 0 | 1 | 20 | 2 | 0 | 3.60 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 30 | 30 | 9 | 11 | 5.76 | .339 | 1.52 | 10.7 | 3.0 | 5.0 | 218.2 | 260 | 144 | 140 | 40 | 72 | 122 | 6 | 0 | 0 | 1 | 8 | 4 | 2 | 5.31 |
| SP | Seaver, T.Seaver, Tom $ >> | 27 | 1971 | R | 71 | 29 | 29 | 7 | 17 | 6.49 | .357 | 1.64 | 10.6 | 4.1 | 7.6 | 194.0 | 229 | 148 | 140 | 33 | 89 | 164 | 3 | 0 | 0 | 0 | 6 | 5 | 3 | 4.97 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 98 | 53 | 0 | 7 | 7 | 3.68 | .277 | 1.15 | 6.4 | 4.0 | 8.1 | 63.2 | 45 | 26 | 26 | 3 | 28 | 57 | 0 | 26 | 7 | 0 | 0 | 0 | 0 | 3.14 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 54 | 0 | 5 | 3 | 5.06 | .342 | 1.54 | 9.2 | 4.8 | 6.3 | 53.1 | 54 | 30 | 30 | 6 | 28 | 37 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.72 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 81 | 36 | 0 | 2 | 1 | 4.23 | .324 | 1.38 | 9.0 | 3.6 | 9.7 | 38.1 | 38 | 18 | 18 | 4 | 15 | 41 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.55 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 23 | 0 | 1 | 1 | 4.73 | .333 | 1.50 | 10.7 | 3.1 | 8.0 | 26.2 | 31 | 17 | 14 | 6 | 9 | 23 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 5.27 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 23 | 0 | 1 | 0 | 4.45 | .309 | 1.34 | 9.3 | 2.9 | 8.0 | 28.1 | 29 | 15 | 14 | 3 | 9 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.57 |