| SP | Koufax, S.Koufax, Sandy † # >> | 30 | 1965 | L | 97 | 31 | 31 | 17 | 11 | 3.13 | .252 | 0.99 | 6.9 | 2.0 | 8.4 | 259.0 | 199 | 90 | 90 | 35 | 58 | 241 | 16 | 0 | 0 | 5 | 20 | 5 | 4 | 3.63 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 30 | 30 | 8 | 16 | 5.64 | .323 | 1.42 | 10.2 | 2.6 | 4.3 | 167.2 | 190 | 108 | 105 | 29 | 48 | 79 | 0 | 0 | 0 | 0 | 10 | 2 | 2 | 5.21 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 30 | 30 | 5 | 23 | 5.41 | .332 | 1.48 | 9.7 | 3.6 | 5.2 | 218.0 | 236 | 134 | 131 | 39 | 86 | 126 | 11 | 0 | 0 | 1 | 10 | 3 | 2 | 5.39 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 30 | 30 | 9 | 17 | 5.43 | .323 | 1.41 | 8.6 | 4.0 | 5.5 | 205.2 | 197 | 130 | 124 | 29 | 92 | 126 | 3 | 0 | 0 | 0 | 14 | 5 | 6 | 5.03 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 76 | 0 | 2 | 3 | 4.53 | .288 | 1.19 | 6.9 | 3.8 | 9.0 | 105.1 | 81 | 53 | 53 | 18 | 44 | 105 | 0 | 5 | 5 | 0 | 0 | 3 | 4 | 4.57 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 69 | 66 | 0 | 1 | 2 | 4.07 | .286 | 1.18 | 6.8 | 3.9 | 6.0 | 90.2 | 68 | 44 | 41 | 14 | 39 | 60 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 5.06 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 49 | 0 | 4 | 3 | 4.01 | .294 | 1.20 | 7.4 | 3.4 | 5.3 | 58.1 | 48 | 28 | 26 | 2 | 22 | 34 | 0 | 4 | 1 | 0 | 0 | 3 | 1 | 3.57 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 41 | 0 | 0 | 3 | 4.60 | .352 | 1.58 | 8.0 | 6.3 | 9.6 | 43.0 | 38 | 23 | 22 | 4 | 30 | 46 | 0 | 2 | 1 | 0 | 0 | 2 | 4 | 4.30 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 22 | 0 | 3 | 3 | 5.50 | .360 | 1.69 | 11.1 | 4.2 | 7.1 | 34.1 | 42 | 21 | 21 | 8 | 16 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.88 |