| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 18 | 18 | 8 | 6 | 3.85 | .305 | 1.25 | 8.2 | 3.1 | 8.1 | 126.1 | 115 | 55 | 54 | 15 | 43 | 113 | 0 | 0 | 0 | 0 | 10 | 8 | 3 | 3.97 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 18 | 18 | 7 | 6 | 4.41 | .298 | 1.28 | 8.2 | 3.3 | 7.5 | 122.1 | 111 | 60 | 60 | 15 | 45 | 102 | 2 | 0 | 0 | 1 | 9 | 0 | 1 | 4.03 |
| SP | Mathewson, C.Mathewson, Christy † # >> | 28 | 1908 | R | 82 | 17 | 17 | 9 | 4 | 2.80 | .244 | 0.94 | 7.3 | 1.1 | 4.8 | 135.0 | 110 | 50 | 42 | 7 | 17 | 72 | 3 | 0 | 0 | 1 | 13 | 4 | 0 | 3.07 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 17 | 17 | 7 | 6 | 4.99 | .320 | 1.40 | 8.8 | 3.8 | 8.2 | 106.1 | 104 | 65 | 59 | 14 | 45 | 96 | 0 | 0 | 0 | 0 | 9 | 1 | 1 | 4.21 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 17 | 17 | 9 | 4 | 3.37 | .275 | 1.13 | 6.1 | 4.1 | 4.4 | 120.1 | 81 | 47 | 45 | 5 | 55 | 58 | 0 | 0 | 0 | 0 | 12 | 1 | 3 | 3.98 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 29 | 0 | 1 | 4 | 3.38 | .307 | 1.33 | 6.2 | 5.9 | 8.7 | 29.1 | 20 | 11 | 11 | 5 | 19 | 28 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 5.28 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 16 | 0 | 1 | 1 | 4.97 | .333 | 1.50 | 9.8 | 4.5 | 9.0 | 12.2 | 13 | 7 | 7 | 2 | 6 | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.67 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 11 | 0 | 1 | 0 | 6.23 | .371 | 1.77 | 8.3 | 7.6 | 6.9 | 13.0 | 12 | 9 | 9 | 3 | 11 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.00 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 36 | 0 | 0 | 3 | 3.55 | .277 | 1.15 | 6.3 | 4.1 | 9.8 | 33.0 | 23 | 13 | 13 | 2 | 15 | 36 | 0 | 26 | 5 | 0 | 0 | 0 | 2 | 2.97 |