| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 31 | 31 | 7 | 11 | 5.26 | .329 | 1.46 | 9.1 | 4.0 | 10.2 | 171.0 | 173 | 101 | 100 | 25 | 76 | 193 | 0 | 0 | 0 | 0 | 15 | 3 | 3 | 4.03 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 32 | 31 | 7 | 14 | 7.30 | .370 | 1.73 | 12.3 | 3.3 | 9.6 | 144.1 | 197 | 120 | 117 | 34 | 53 | 153 | 0 | 0 | 0 | 0 | 9 | 4 | 3 | 5.13 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 30 | 7 | 11 | 5.37 | .340 | 1.52 | 10.0 | 3.7 | 7.7 | 162.2 | 180 | 102 | 97 | 23 | 67 | 139 | 1 | 0 | 0 | 0 | 12 | 4 | 4 | 4.44 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 30 | 30 | 15 | 6 | 3.59 | .299 | 1.26 | 9.2 | 2.2 | 4.8 | 208.1 | 212 | 88 | 83 | 21 | 51 | 110 | 4 | 0 | 0 | 0 | 21 | 4 | 5 | 4.05 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 97 | 85 | 0 | 12 | 8 | 3.39 | .282 | 1.16 | 6.6 | 3.8 | 10.6 | 103.2 | 76 | 40 | 39 | 11 | 44 | 121 | 0 | 29 | 7 | 0 | 0 | 2 | 1 | 3.38 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 87 | 0 | 6 | 9 | 4.64 | .315 | 1.35 | 8.0 | 4.2 | 9.5 | 95.0 | 84 | 52 | 49 | 19 | 44 | 100 | 0 | 4 | 8 | 0 | 0 | 3 | 0 | 4.98 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 59 | 0 | 6 | 2 | 3.48 | .304 | 1.30 | 7.4 | 4.4 | 11.9 | 77.2 | 63 | 31 | 30 | 13 | 38 | 102 | 0 | 0 | 1 | 0 | 0 | 1 | 6 | 4.06 |