| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 21 | 21 | 8 | 9 | 4.36 | .317 | 1.36 | 10.3 | 1.9 | 10.3 | 132.0 | 151 | 64 | 64 | 17 | 28 | 151 | 0 | 0 | 0 | 0 | 11 | 5 | 6 | 3.14 |
| SP | Kelly, M.Kelly, Merrill >> | 36 | 2025 | R | 73 | 20 | 20 | 7 | 10 | 5.26 | .355 | 1.60 | 10.7 | 3.7 | 8.1 | 104.1 | 124 | 66 | 61 | 17 | 43 | 94 | 1 | 0 | 0 | 0 | 8 | 5 | 2 | 4.70 |
| SP | Littell, Z.Littell, Zack >> | 29 | 2025 | R | 65 | 20 | 20 | 5 | 8 | 5.24 | .347 | 1.54 | 10.8 | 3.1 | 5.7 | 113.1 | 136 | 66 | 66 | 14 | 39 | 72 | 0 | 0 | 0 | 0 | 8 | 6 | 3 | 4.53 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 60 | 20 | 20 | 5 | 8 | 5.51 | .351 | 1.59 | 10.4 | 3.9 | 6.8 | 96.1 | 111 | 61 | 59 | 11 | 42 | 72 | 0 | 0 | 0 | 0 | 5 | 3 | 4 | 4.40 |
| RP | Bautista, F.Bautista, Félix >> | 30 | 2025 | R | 84 | 51 | 0 | 6 | 2 | 4.52 | .337 | 1.46 | 6.5 | 6.8 | 11.7 | 69.2 | 50 | 35 | 35 | 6 | 52 | 90 | 0 | 0 | 2 | 0 | 0 | 4 | 2 | 3.96 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 73 | 55 | 0 | 3 | 4 | 2.11 | .283 | 1.13 | 7.5 | 2.8 | 12.5 | 72.2 | 60 | 19 | 17 | 3 | 22 | 100 | 0 | 4 | 4 | 0 | 0 | 4 | 4 | 1.85 |
| RP | Pomeranz, D.Pomeranz, Drew >> | 36 | 2025 | L | 70 | 46 | 0 | 3 | 1 | 4.88 | .335 | 1.47 | 7.9 | 5.5 | 10.2 | 51.2 | 45 | 28 | 28 | 7 | 31 | 58 | 0 | 5 | 1 | 0 | 0 | 2 | 1 | 4.45 |
| RP | Rodríguez, Y.Rodríguez, Yariel >> | 28 | 2025 | R | 66 | 34 | 0 | 2 | 0 | 3.07 | .255 | 1.00 | 5.0 | 4.0 | 7.5 | 41.0 | 23 | 14 | 14 | 9 | 18 | 34 | 0 | 7 | 0 | 0 | 0 | 1 | 1 | 5.59 |
| RP | Gaddis, H.Gaddis, Hunter >> | 27 | 2025 | R | 52 | 26 | 0 | 1 | 0 | 4.08 | .289 | 1.19 | 8.5 | 2.3 | 12.6 | 35.1 | 33 | 16 | 16 | 7 | 9 | 49 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.66 |
| SP | Wacha, M.Wacha, Michael >> | 33 | 2025 | R | 49 | 13 | 0 | 2 | 0 | 5.57 | .364 | 1.67 | 12.4 | 2.6 | 9.0 | 21.0 | 29 | 13 | 13 | 4 | 6 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.48 |