| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 20 | 20 | 9 | 10 | 4.86 | .303 | 1.28 | 9.5 | 2.0 | 9.6 | 120.1 | 127 | 68 | 65 | 16 | 27 | 128 | 0 | 0 | 0 | 0 | 9 | 3 | 0 | 3.35 |
| SP | Glasnow, T.Glasnow, Tyler † >> | 31 | 2025 | R | 88 | 19 | 19 | 10 | 3 | 3.51 | .264 | 1.07 | 6.3 | 3.3 | 8.1 | 105.0 | 74 | 44 | 41 | 14 | 38 | 94 | 0 | 0 | 0 | 0 | 8 | 1 | 8 | 4.06 |
| SP | Imanaga, S.Imanaga, Shota # >> | 31 | 2025 | L | 83 | 19 | 19 | 8 | 4 | 3.98 | .294 | 1.21 | 8.8 | 2.3 | 8.3 | 108.2 | 105 | 48 | 48 | 16 | 27 | 99 | 0 | 0 | 0 | 0 | 10 | 4 | 0 | 3.95 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 68 | 19 | 19 | 6 | 6 | 5.59 | .330 | 1.41 | 9.5 | 3.3 | 11.1 | 96.2 | 101 | 60 | 60 | 16 | 35 | 118 | 0 | 0 | 0 | 0 | 10 | 7 | 1 | 4.02 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 90 | 50 | 0 | 2 | 4 | 2.79 | .254 | 1.00 | 6.9 | 2.3 | 7.3 | 67.2 | 51 | 21 | 21 | 5 | 17 | 54 | 0 | 4 | 5 | 0 | 0 | 1 | 0 | 3.16 |
| RP | Clarke, T.Clarke, Taylor >> | 32 | 2025 | R | 87 | 41 | 0 | 0 | 1 | 2.50 | .304 | 1.27 | 7.4 | 4.1 | 7.9 | 50.1 | 41 | 14 | 14 | 4 | 23 | 44 | 0 | 8 | 5 | 0 | 0 | 2 | 1 | 3.78 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 78 | 20 | 0 | 1 | 2 | 5.14 | .323 | 1.38 | 9.0 | 3.4 | 8.6 | 21.0 | 21 | 12 | 12 | 2 | 8 | 20 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.62 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 71 | 23 | 0 | 3 | 2 | 4.21 | .342 | 1.52 | 8.6 | 5.4 | 10.4 | 25.2 | 24 | 12 | 12 | 3 | 15 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.16 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 67 | 18 | 0 | 4 | 2 | 3.60 | .328 | 1.46 | 9.6 | 3.6 | 9.1 | 80.0 | 85 | 35 | 32 | 10 | 32 | 81 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.80 |