| SP | Scherzer, M.Scherzer, Max >> | 31 | 2015 | R | 100 | 26 | 26 | 8 | 11 | 3.55 | .294 | 1.22 | 7.9 | 3.1 | 8.5 | 177.1 | 156 | 76 | 70 | 12 | 60 | 168 | 1 | 0 | 0 | 0 | 18 | 6 | 10 | 3.10 |
| SP | Pena, A.Pena, Alejandro >> | 24 | 1983 | R | 83 | 25 | 25 | 10 | 4 | 4.12 | .328 | 1.44 | 9.7 | 3.3 | 5.4 | 129.0 | 139 | 65 | 59 | 14 | 47 | 77 | 0 | 0 | 0 | 0 | 9 | 3 | 2 | 4.38 |
| SP | Gooden, D.Gooden, Dwight >> | 29 | 1993 | R | 74 | 25 | 25 | 10 | 6 | 4.16 | .316 | 1.38 | 9.0 | 3.4 | 5.6 | 158.0 | 158 | 93 | 73 | 19 | 60 | 98 | 3 | 0 | 0 | 1 | 13 | 1 | 4 | 4.48 |
| SP | Ditmar, A.Ditmar, Art # >> | 31 | 1960 | R | 56 | 25 | 25 | 8 | 11 | 5.16 | .322 | 1.40 | 9.6 | 3.0 | 4.6 | 144.2 | 154 | 85 | 83 | 20 | 48 | 74 | 0 | 0 | 0 | 0 | 12 | 4 | 5 | 4.86 |
| SP | Gromek, S.Gromek, Steve >> | 35 | 1955 | R | 54 | 26 | 24 | 9 | 7 | 4.13 | .302 | 1.29 | 9.1 | 2.6 | 4.3 | 150.1 | 151 | 75 | 69 | 23 | 43 | 72 | 2 | 0 | 0 | 0 | 14 | 1 | 3 | 4.91 |
| RP | Isringhausen, J.Isringhausen, Jason # >> | 31 | 2003 | R | 84 | 73 | 0 | 2 | 6 | 3.67 | .329 | 1.43 | 9.2 | 3.7 | 8.1 | 81.0 | 83 | 37 | 33 | 6 | 33 | 73 | 0 | 7 | 2 | 0 | 0 | 3 | 6 | 3.49 |
| RP | Tolleson, S.Tolleson, Shawn † >> | 27 | 2015 | R | 75 | 60 | 0 | 5 | 0 | 3.20 | .276 | 1.13 | 7.3 | 2.8 | 9.2 | 76.0 | 62 | 27 | 27 | 9 | 24 | 78 | 0 | 14 | 1 | 0 | 0 | 1 | 0 | 3.47 |