| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 29 | 29 | 10 | 11 | 4.05 | .308 | 1.33 | 8.2 | 3.8 | 9.9 | 182.1 | 165 | 83 | 82 | 23 | 77 | 200 | 1 | 0 | 0 | 1 | 16 | 2 | 6 | 3.75 |
| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 72 | 28 | 28 | 11 | 14 | 4.75 | .322 | 1.39 | 9.1 | 3.5 | 6.5 | 185.2 | 187 | 100 | 98 | 36 | 72 | 134 | 4 | 0 | 0 | 1 | 13 | 5 | 6 | 5.33 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 60 | 27 | 27 | 8 | 15 | 4.93 | .337 | 1.51 | 8.9 | 4.7 | 7.4 | 173.1 | 172 | 105 | 95 | 35 | 90 | 142 | 2 | 0 | 0 | 0 | 10 | 2 | 3 | 5.58 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 57 | 26 | 26 | 10 | 14 | 5.10 | .330 | 1.44 | 10.5 | 2.5 | 6.0 | 167.2 | 195 | 100 | 95 | 31 | 46 | 111 | 5 | 0 | 0 | 0 | 14 | 7 | 4 | 5.04 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 73 | 0 | 4 | 3 | 2.50 | .275 | 1.12 | 6.6 | 3.5 | 9.4 | 115.1 | 84 | 34 | 32 | 11 | 45 | 120 | 0 | 8 | 3 | 0 | 0 | 2 | 0 | 3.38 |
| RP | Pagan, E.Pagan, Emilio # >> | 28 | 2019 | R | 72 | 64 | 0 | 4 | 2 | 4.90 | .293 | 1.24 | 7.6 | 3.7 | 10.3 | 71.2 | 60 | 39 | 39 | 12 | 29 | 81 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 4.14 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 49 | 0 | 0 | 2 | 3.10 | .307 | 1.30 | 7.1 | 4.6 | 11.2 | 61.0 | 48 | 21 | 21 | 5 | 31 | 76 | 0 | 7 | 1 | 0 | 0 | 2 | 3 | 3.20 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 56 | 35 | 0 | 0 | 4 | 3.47 | .282 | 1.11 | 7.0 | 3.1 | 4.9 | 46.2 | 36 | 18 | 18 | 2 | 16 | 25 | 0 | 2 | 1 | 0 | 0 | 3 | 2 | 3.72 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 52 | 6 | 0 | 0 | 0 | 5.87 | .439 | 2.35 | 11.6 | 11.6 | 7.7 | 7.2 | 9 | 5 | 5 | 0 | 9 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.14 |