| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 30 | 30 | 13 | 7 | 2.76 | .244 | 0.95 | 6.5 | 2.0 | 10.8 | 202.1 | 147 | 68 | 62 | 32 | 46 | 242 | 2 | 0 | 0 | 1 | 22 | 3 | 0 | 3.39 |
| SP | Santana, J.Santana, Johan † # >> | 25 | 2004 | L | 91 | 30 | 30 | 17 | 7 | 3.97 | .296 | 1.23 | 8.3 | 2.8 | 8.0 | 204.0 | 187 | 93 | 90 | 33 | 63 | 182 | 1 | 0 | 0 | 1 | 18 | 7 | 2 | 4.35 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 29 | 29 | 9 | 6 | 4.11 | .313 | 1.33 | 8.8 | 3.3 | 8.2 | 135.2 | 132 | 64 | 62 | 16 | 49 | 123 | 0 | 0 | 0 | 0 | 1 | 4 | 5 | 3.90 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 83 | 0 | 9 | 3 | 2.61 | .260 | 1.02 | 5.1 | 4.0 | 8.9 | 114.0 | 65 | 33 | 33 | 8 | 51 | 113 | 0 | 14 | 2 | 0 | 0 | 4 | 1 | 3.38 |
| RP | Jackson, M.Jackson, Mike † >> | 30 | 1994 | R | 81 | 56 | 0 | 9 | 3 | 2.73 | .288 | 1.21 | 6.8 | 4.1 | 9.7 | 66.0 | 50 | 20 | 20 | 9 | 30 | 71 | 0 | 9 | 1 | 0 | 0 | 0 | 0 | 3.98 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 32 | 0 | 2 | 4 | 4.46 | .290 | 1.17 | 7.8 | 2.8 | 9.2 | 38.1 | 33 | 19 | 19 | 5 | 12 | 39 | 0 | 5 | 4 | 0 | 0 | 2 | 1 | 3.76 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 66 | 18 | 0 | 1 | 1 | 3.31 | .290 | 1.22 | 7.3 | 3.9 | 6.8 | 16.1 | 13 | 6 | 6 | 2 | 7 | 12 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 4.44 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 26 | 0 | 1 | 0 | 3.18 | .336 | 1.52 | 9.0 | 4.8 | 10.0 | 28.1 | 28 | 11 | 10 | 3 | 15 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.79 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 3 | 2 | 0 | 1 | 7.50 | .321 | 1.42 | 11.3 | 1.5 | 6.0 | 12.0 | 15 | 10 | 10 | 5 | 2 | 8 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 7.58 |