| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 34 | 34 | 13 | 14 | 4.73 | .323 | 1.40 | 8.9 | 3.8 | 7.8 | 218.2 | 215 | 117 | 115 | 31 | 91 | 189 | 3 | 0 | 0 | 2 | 13 | 7 | 2 | 4.46 |
| SP | Alvarez, W.Alvarez, Wilson # >> | 33 | 2003 | L | 73 | 33 | 33 | 3 | 14 | 5.59 | .338 | 1.47 | 10.1 | 3.2 | 6.9 | 140.0 | 157 | 93 | 87 | 14 | 49 | 107 | 0 | 0 | 0 | 0 | 2 | 8 | 2 | 3.99 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 32 | 32 | 12 | 13 | 5.61 | .341 | 1.51 | 10.4 | 3.2 | 5.7 | 200.2 | 232 | 137 | 125 | 32 | 72 | 126 | 4 | 0 | 0 | 0 | 15 | 7 | 1 | 5.01 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 50 | 32 | 32 | 9 | 13 | 5.74 | .332 | 1.45 | 9.9 | 3.2 | 7.4 | 185.0 | 203 | 124 | 118 | 33 | 66 | 153 | 1 | 0 | 0 | 0 | 14 | 7 | 3 | 4.85 |
| SP | Ortiz, R.Ortiz, Ramon # >> | 29 | 2002 | R | 37 | 31 | 31 | 12 | 8 | 4.86 | .342 | 1.53 | 10.2 | 3.6 | 7.2 | 183.1 | 207 | 101 | 99 | 24 | 73 | 146 | 0 | 0 | 0 | 0 | 14 | 6 | 8 | 4.40 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 89 | 0 | 7 | 5 | 4.06 | .306 | 1.32 | 8.8 | 3.1 | 9.5 | 119.2 | 117 | 57 | 54 | 17 | 41 | 126 | 0 | 6 | 9 | 0 | 0 | 0 | 5 | 3.77 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 71 | 0 | 5 | 3 | 4.53 | .302 | 1.29 | 9.3 | 2.3 | 6.1 | 93.1 | 96 | 53 | 47 | 18 | 24 | 63 | 0 | 9 | 5 | 0 | 0 | 1 | 2 | 4.97 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 37 | 66 | 0 | 3 | 4 | 5.97 | .382 | 1.82 | 11.2 | 5.3 | 9.8 | 66.1 | 82 | 44 | 44 | 12 | 39 | 72 | 0 | 5 | 3 | 0 | 0 | 2 | 6 | 5.05 |
| SP | Person, R.Person, Robert >> | 32 | 2001 | R | 26 | 21 | 0 | 1 | 2 | 8.12 | .418 | 2.02 | 13.4 | 5.1 | 4.6 | 37.2 | 55 | 36 | 34 | 4 | 21 | 19 | 0 | 1 | 2 | 0 | 0 | 5 | 1 | 5.49 |