| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 37 | 37 | 18 | 10 | 3.21 | .296 | 1.22 | 7.0 | 4.0 | 10.0 | 224.0 | 174 | 84 | 80 | 24 | 100 | 250 | 0 | 0 | 0 | 0 | 19 | 8 | 1 | 3.61 |
| SP | Hamels, C.Hamels, Cole # >> | 25 | 2008 | L | 72 | 36 | 36 | 14 | 15 | 5.27 | .313 | 1.35 | 9.5 | 2.7 | 7.1 | 229.0 | 241 | 138 | 134 | 47 | 68 | 181 | 5 | 0 | 0 | 1 | 17 | 4 | 0 | 5.03 |
| SP | Santana, E.Santana, Ervin # >> | 25 | 2008 | R | 55 | 35 | 35 | 10 | 13 | 5.33 | .327 | 1.44 | 9.8 | 3.2 | 7.5 | 199.1 | 216 | 129 | 118 | 30 | 71 | 166 | 2 | 0 | 0 | 0 | 13 | 4 | 6 | 4.42 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 52 | 34 | 34 | 8 | 14 | 4.94 | .321 | 1.39 | 9.5 | 3.0 | 6.4 | 207.2 | 218 | 125 | 114 | 30 | 70 | 148 | 1 | 0 | 0 | 1 | 13 | 6 | 3 | 4.56 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 31 | 31 | 12 | 11 | 5.38 | .339 | 1.52 | 9.4 | 4.3 | 7.0 | 174.0 | 181 | 107 | 104 | 30 | 84 | 136 | 0 | 0 | 0 | 0 | 16 | 3 | 1 | 5.18 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 73 | 95 | 0 | 7 | 5 | 4.03 | .309 | 1.33 | 8.1 | 3.9 | 5.6 | 109.1 | 98 | 49 | 49 | 9 | 47 | 68 | 0 | 10 | 3 | 0 | 0 | 2 | 3 | 4.17 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 113 | 0 | 4 | 3 | 2.72 | .250 | 0.99 | 6.2 | 2.7 | 6.8 | 86.0 | 59 | 26 | 26 | 10 | 26 | 65 | 0 | 4 | 4 | 0 | 0 | 1 | 0 | 3.94 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 71 | 0 | 5 | 1 | 2.72 | .281 | 1.15 | 6.7 | 3.6 | 9.8 | 79.1 | 59 | 26 | 24 | 3 | 32 | 86 | 0 | 11 | 2 | 0 | 0 | 2 | 0 | 2.61 |