| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 11 | 11 | 2 | 3 | 3.91 | .284 | 1.19 | 8.5 | 2.2 | 9.3 | 53.0 | 50 | 24 | 23 | 7 | 13 | 55 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.38 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 80 | 11 | 11 | 5 | 3 | 3.41 | .270 | 1.08 | 7.1 | 2.7 | 8.4 | 74.0 | 58 | 28 | 28 | 8 | 22 | 69 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 3.51 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 76 | 11 | 11 | 5 | 2 | 3.86 | .309 | 1.30 | 7.5 | 4.3 | 9.1 | 72.1 | 60 | 32 | 31 | 8 | 34 | 73 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 3.96 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 95 | 27 | 0 | 3 | 3 | 3.38 | .240 | 0.95 | 6.4 | 2.2 | 9.8 | 45.1 | 32 | 17 | 17 | 9 | 11 | 49 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.16 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 26 | 0 | 4 | 1 | 3.38 | .304 | 1.31 | 6.3 | 5.6 | 10.0 | 37.1 | 26 | 14 | 14 | 6 | 23 | 41 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 4.76 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 30 | 0 | 3 | 1 | 1.88 | .243 | 0.94 | 5.7 | 2.8 | 10.4 | 38.1 | 24 | 8 | 8 | 6 | 12 | 44 | 0 | 7 | 0 | 0 | 0 | 1 | 0 | 3.76 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 20 | 0 | 1 | 1 | 4.35 | .319 | 1.40 | 9.5 | 3.6 | 8.1 | 20.2 | 21 | 11 | 10 | 2 | 8 | 18 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.70 |
| RP | Aardsma, D.Aardsma, David >> | 28 | 2009 | R | 38 | 17 | 0 | 2 | 1 | 1.69 | .264 | 1.03 | 5.1 | 4.3 | 12.0 | 21.1 | 12 | 4 | 4 | 1 | 10 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 2.52 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 47 | 9 | 0 | 2 | 2 | 4.50 | .304 | 1.31 | 9.0 | 2.8 | 7.9 | 16.0 | 16 | 8 | 8 | 4 | 5 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 5.44 |