| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 11 | 11 | 4 | 5 | 3.77 | .287 | 1.21 | 8.4 | 2.5 | 7.3 | 76.1 | 71 | 33 | 32 | 14 | 21 | 62 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 4.59 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 87 | 11 | 11 | 3 | 5 | 4.17 | .328 | 1.45 | 11.1 | 2.0 | 5.7 | 82.0 | 101 | 41 | 38 | 8 | 18 | 52 | 2 | 0 | 0 | 1 | 6 | 1 | 0 | 3.70 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 79 | 11 | 11 | 6 | 3 | 5.10 | .314 | 1.34 | 10.3 | 1.7 | 5.5 | 67.0 | 77 | 39 | 38 | 8 | 13 | 41 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 4.00 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 12 | 11 | 3 | 5 | 7.02 | .388 | 1.85 | 12.7 | 4.0 | 5.8 | 59.0 | 83 | 48 | 46 | 9 | 26 | 38 | 1 | 0 | 0 | 0 | 3 | 3 | 1 | 5.17 |
| CL | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 99 | 21 | 0 | 0 | 1 | 2.25 | .294 | 1.20 | 5.4 | 5.4 | 9.0 | 20.0 | 12 | 5 | 5 | 4 | 12 | 20 | 0 | 15 | 1 | 0 | 0 | 1 | 0 | 5.55 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 31 | 0 | 1 | 0 | 3.96 | .257 | 1.00 | 5.8 | 3.2 | 9.7 | 25.0 | 16 | 11 | 11 | 5 | 9 | 27 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.64 |
| RP | Remlinger, M.Remlinger, Mike >> | 36 | 2002 | L | 36 | 24 | 0 | 0 | 0 | 2.77 | .304 | 1.31 | 8.3 | 3.5 | 6.2 | 13.0 | 12 | 4 | 4 | 1 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.77 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 16 | 0 | 1 | 0 | 4.05 | .259 | 1.05 | 4.8 | 4.8 | 11.1 | 13.1 | 7 | 6 | 6 | 3 | 7 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.15 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 33 | 22 | 0 | 2 | 2 | 6.11 | .418 | 2.09 | 13.2 | 6.4 | 9.5 | 17.2 | 25 | 12 | 12 | 5 | 12 | 18 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 7.00 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 9 | 0 | 2 | 0 | 7.18 | .325 | 1.37 | 10.4 | 2.1 | 7.3 | 26.1 | 30 | 22 | 21 | 9 | 6 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 6.81 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |