| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 31 | 31 | 10 | 16 | 4.59 | .308 | 1.31 | 9.6 | 2.1 | 4.8 | 223.2 | 239 | 120 | 114 | 28 | 53 | 120 | 6 | 0 | 0 | 0 | 15 | 6 | 2 | 4.35 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 82 | 31 | 31 | 12 | 12 | 4.24 | .298 | 1.25 | 9.0 | 2.3 | 4.8 | 214.1 | 213 | 112 | 101 | 24 | 54 | 114 | 7 | 0 | 0 | 0 | 17 | 6 | 1 | 4.23 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 63 | 30 | 30 | 8 | 15 | 5.79 | .351 | 1.58 | 9.6 | 4.6 | 4.1 | 168.0 | 179 | 120 | 108 | 25 | 86 | 77 | 0 | 0 | 0 | 0 | 12 | 7 | 5 | 5.68 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 81 | 0 | 8 | 6 | 4.69 | .299 | 1.26 | 9.2 | 2.2 | 8.8 | 113.1 | 116 | 62 | 59 | 13 | 27 | 111 | 0 | 4 | 6 | 0 | 0 | 2 | 2 | 3.30 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 63 | 0 | 2 | 5 | 5.26 | .338 | 1.52 | 9.2 | 4.4 | 6.0 | 77.0 | 79 | 52 | 45 | 15 | 38 | 51 | 0 | 3 | 6 | 0 | 0 | 1 | 0 | 5.73 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 59 | 0 | 2 | 1 | 4.60 | .318 | 1.40 | 9.4 | 3.3 | 4.8 | 72.1 | 75 | 43 | 37 | 12 | 26 | 38 | 0 | 8 | 0 | 0 | 0 | 0 | 1 | 5.19 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 45 | 0 | 4 | 3 | 3.09 | .313 | 1.35 | 6.8 | 5.5 | 5.3 | 84.1 | 63 | 31 | 29 | 10 | 51 | 49 | 0 | 6 | 2 | 0 | 0 | 1 | 3 | 5.24 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 3 | 0 | 0 | 1 | 6.75 | .500 | 3.00 | 22.5 | 13.5 | 0.0 | 2.2 | 5 | 2 | 2 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 7.50 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 23 | 0 | 4 | 3 | 5.80 | .378 | 1.80 | 12.4 | 3.8 | 5.4 | 45.0 | 62 | 31 | 29 | 6 | 19 | 27 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.87 |