| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 31 | 31 | 16 | 9 | 3.33 | .282 | 1.16 | 7.3 | 3.1 | 8.4 | 249.0 | 203 | 102 | 92 | 28 | 87 | 232 | 12 | 0 | 0 | 2 | 17 | 3 | 2 | 3.68 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 30 | 30 | 11 | 14 | 4.32 | .299 | 1.27 | 8.3 | 3.2 | 7.1 | 208.1 | 191 | 100 | 100 | 28 | 74 | 163 | 4 | 0 | 0 | 3 | 16 | 2 | 6 | 4.28 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 30 | 30 | 9 | 14 | 5.72 | .343 | 1.54 | 10.2 | 3.7 | 5.8 | 198.1 | 224 | 129 | 126 | 31 | 81 | 128 | 6 | 0 | 0 | 0 | 14 | 6 | 3 | 5.06 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 28 | 28 | 10 | 12 | 5.69 | .342 | 1.54 | 8.8 | 5.2 | 4.2 | 183.1 | 178 | 118 | 116 | 27 | 105 | 86 | 1 | 0 | 0 | 1 | 12 | 3 | 3 | 5.75 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 76 | 0 | 8 | 2 | 1.92 | .262 | 1.05 | 6.2 | 3.3 | 8.1 | 98.2 | 68 | 23 | 21 | 8 | 36 | 88 | 0 | 17 | 3 | 0 | 0 | 1 | 3 | 3.40 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 63 | 0 | 5 | 3 | 3.24 | .290 | 1.21 | 8.3 | 2.6 | 7.3 | 75.0 | 69 | 33 | 27 | 4 | 22 | 61 | 0 | 9 | 5 | 0 | 0 | 1 | 0 | 2.99 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 61 | 31 | 0 | 3 | 1 | 3.46 | .277 | 1.15 | 6.8 | 3.7 | 6.6 | 41.2 | 31 | 16 | 16 | 4 | 17 | 30 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 4.05 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 9 | 0 | 0 | 1 | 1.59 | .320 | 1.41 | 8.2 | 4.9 | 10.6 | 11.1 | 10 | 3 | 2 | 0 | 6 | 13 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.27 |