| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 31 | 31 | 15 | 12 | 4.61 | .328 | 1.44 | 10.6 | 2.3 | 8.2 | 203.0 | 240 | 114 | 104 | 23 | 52 | 184 | 3 | 0 | 0 | 1 | 14 | 5 | 4 | 3.50 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 30 | 30 | 16 | 7 | 3.48 | .279 | 1.15 | 7.5 | 2.8 | 5.0 | 191.1 | 160 | 80 | 74 | 17 | 60 | 107 | 0 | 0 | 0 | 0 | 17 | 2 | 5 | 4.01 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 30 | 30 | 10 | 11 | 5.10 | .331 | 1.46 | 10.1 | 3.1 | 8.1 | 199.1 | 224 | 130 | 113 | 31 | 68 | 179 | 2 | 0 | 0 | 0 | 12 | 4 | 5 | 4.31 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 30 | 30 | 11 | 7 | 4.39 | .309 | 1.33 | 8.3 | 3.8 | 8.0 | 184.1 | 169 | 99 | 90 | 19 | 77 | 163 | 1 | 0 | 0 | 1 | 17 | 1 | 4 | 3.84 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 57 | 0 | 0 | 1 | 2.31 | .283 | 1.16 | 7.9 | 2.7 | 10.8 | 50.2 | 44 | 13 | 13 | 5 | 15 | 60 | 0 | 47 | 4 | 0 | 0 | 1 | 1 | 2.86 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 62 | 0 | 3 | 2 | 3.88 | .292 | 1.19 | 6.4 | 4.4 | 8.7 | 69.2 | 49 | 32 | 30 | 3 | 34 | 67 | 0 | 4 | 5 | 0 | 0 | 3 | 0 | 3.23 |
| RP | Soriano, R.Soriano, Rafael # >> | 24 | 2003 | R | 84 | 70 | 0 | 4 | 3 | 4.56 | .349 | 1.56 | 9.8 | 4.3 | 9.3 | 71.0 | 77 | 37 | 36 | 10 | 34 | 73 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 4.34 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 65 | 58 | 0 | 8 | 1 | 2.63 | .270 | 1.05 | 6.8 | 2.6 | 10.2 | 65.0 | 49 | 22 | 19 | 7 | 19 | 74 | 0 | 1 | 1 | 0 | 0 | 4 | 0 | 3.18 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 74 | 39 | 0 | 4 | 2 | 3.49 | .318 | 1.40 | 8.8 | 4.0 | 9.5 | 38.2 | 37 | 17 | 15 | 4 | 17 | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.61 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 57 | 23 | 0 | 0 | 1 | 6.20 | .371 | 1.77 | 10.8 | 5.4 | 10.8 | 20.1 | 24 | 14 | 14 | 1 | 12 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 3.05 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 10 | 0 | 1 | 0 | 4.06 | .373 | 1.71 | 8.6 | 7.0 | 7.6 | 44.1 | 42 | 24 | 20 | 4 | 34 | 37 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.02 |