| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 31 | 31 | 17 | 7 | 3.58 | .273 | 1.11 | 7.6 | 2.4 | 9.4 | 208.2 | 176 | 87 | 83 | 26 | 55 | 218 | 0 | 0 | 0 | 0 | 21 | 4 | 0 | 3.38 |
| SP | Alexander, P.Alexander, Pete # >> | 28 | 1915 | R | 88 | 30 | 30 | 8 | 18 | 5.10 | .331 | 1.47 | 10.4 | 2.9 | 4.3 | 220.2 | 255 | 131 | 125 | 22 | 70 | 105 | 4 | 0 | 0 | 1 | 11 | 3 | 2 | 4.34 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 67 | 30 | 30 | 10 | 12 | 4.40 | .314 | 1.34 | 9.1 | 3.0 | 7.4 | 214.2 | 216 | 112 | 105 | 29 | 72 | 177 | 6 | 0 | 0 | 0 | 16 | 7 | 7 | 4.21 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 28 | 28 | 13 | 8 | 4.12 | .318 | 1.36 | 9.2 | 3.0 | 3.9 | 218.1 | 223 | 107 | 100 | 27 | 73 | 95 | 11 | 0 | 0 | 0 | 14 | 9 | 1 | 4.87 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 83 | 0 | 2 | 7 | 3.97 | .294 | 1.22 | 7.5 | 3.5 | 8.4 | 95.1 | 79 | 44 | 42 | 14 | 37 | 89 | 0 | 17 | 5 | 0 | 0 | 3 | 1 | 4.31 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 59 | 0 | 7 | 4 | 2.14 | .262 | 1.04 | 6.1 | 3.3 | 8.9 | 80.0 | 54 | 21 | 19 | 6 | 29 | 79 | 0 | 10 | 2 | 0 | 0 | 2 | 2 | 3.16 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 33 | 0 | 1 | 0 | 2.65 | .271 | 1.09 | 8.2 | 1.6 | 9.0 | 34.0 | 31 | 12 | 10 | 6 | 6 | 34 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.91 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 19 | 0 | 2 | 1 | 4.13 | .294 | 1.17 | 5.6 | 4.9 | 8.6 | 24.0 | 15 | 11 | 11 | 3 | 13 | 23 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.58 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 29 | 0 | 2 | 2 | 4.09 | .317 | 1.33 | 9.8 | 2.2 | 8.2 | 33.0 | 36 | 19 | 15 | 6 | 8 | 30 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.45 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 5 | 0 | 1 | 1 | 1.50 | .308 | 1.17 | 3.0 | 7.5 | 4.5 | 6.0 | 2 | 2 | 1 | 0 | 5 | 3 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5.00 |