| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 100 | 31 | 31 | 12 | 9 | 4.10 | .289 | 1.17 | 7.7 | 2.9 | 10.0 | 197.2 | 168 | 93 | 90 | 23 | 63 | 219 | 4 | 0 | 0 | 2 | 19 | 10 | 3 | 3.41 |
| SP | Kluber, C.Kluber, Corey † >> | 32 | 2018 | R | 91 | 29 | 29 | 14 | 6 | 3.43 | .287 | 1.16 | 8.7 | 1.8 | 9.2 | 194.0 | 187 | 83 | 74 | 25 | 39 | 198 | 0 | 0 | 0 | 0 | 20 | 8 | 0 | 3.36 |
| RP | Familia, J.Familia, Jeurys >> | 28 | 2018 | R | 55 | 73 | 0 | 6 | 4 | 4.81 | .325 | 1.41 | 8.8 | 3.9 | 9.5 | 88.0 | 86 | 48 | 47 | 12 | 38 | 93 | 0 | 0 | 5 | 0 | 0 | 3 | 4 | 4.06 |
| RP | Rodriguez, R.Rodriguez, Richard >> | 28 | 2018 | R | 77 | 64 | 0 | 3 | 0 | 3.50 | .296 | 1.26 | 8.3 | 3.1 | 12.0 | 64.1 | 59 | 25 | 25 | 11 | 22 | 85 | 0 | 3 | 2 | 0 | 0 | 0 | 7 | 3.61 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 100 | 53 | 0 | 2 | 7 | 3.07 | .261 | 0.99 | 6.9 | 2.1 | 11.0 | 55.2 | 42 | 20 | 19 | 5 | 13 | 67 | 0 | 25 | 2 | 0 | 0 | 4 | 3 | 2.67 |
| SP | Hamels, C.Hamels, Cole >> | 35 | 2018 | L | 53 | 12 | 0 | 1 | 4 | 10.47 | .430 | 2.20 | 15.2 | 5.1 | 12.4 | 16.1 | 27 | 19 | 19 | 7 | 9 | 22 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 7.81 |
| SU | Robertson, D.Robertson, David >> | 33 | 2018 | R | 89 | 58 | 0 | 1 | 7 | 5.74 | .329 | 1.44 | 8.3 | 4.8 | 10.2 | 62.2 | 57 | 40 | 40 | 8 | 33 | 70 | 0 | 3 | 8 | 0 | 0 | 2 | 1 | 4.11 |
| RP | Fields, J.Fields, Josh >> | 32 | 2018 | R | 87 | 50 | 0 | 2 | 3 | 3.88 | .269 | 1.10 | 6.4 | 3.6 | 7.3 | 58.0 | 41 | 25 | 25 | 7 | 23 | 47 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.14 |