| SP | Scherzer, M.Scherzer, Max † >> | 34 | 2018 | R | 100 | 28 | 28 | 16 | 2 | 2.83 | .267 | 1.06 | 7.3 | 2.3 | 10.3 | 194.1 | 157 | 63 | 61 | 22 | 49 | 223 | 3 | 0 | 0 | 1 | 19 | 6 | 1 | 3.03 |
| SP | Paxton, J.Paxton, James >> | 29 | 2018 | L | 89 | 27 | 27 | 9 | 8 | 4.53 | .343 | 1.53 | 10.8 | 3.0 | 10.3 | 147.0 | 176 | 77 | 74 | 25 | 49 | 168 | 0 | 0 | 0 | 0 | 9 | 5 | 2 | 4.03 |
| SP | Teheran, J.Teheran, Julio >> | 27 | 2018 | R | 83 | 27 | 27 | 11 | 4 | 2.99 | .308 | 1.30 | 7.3 | 4.4 | 8.4 | 156.1 | 127 | 55 | 52 | 8 | 77 | 145 | 0 | 0 | 0 | 0 | 14 | 5 | 4 | 3.38 |
| SP | Clevinger, M.Clevinger, Mike >> | 27 | 2018 | R | 81 | 26 | 26 | 5 | 9 | 4.36 | .319 | 1.36 | 9.3 | 3.0 | 9.4 | 161.0 | 166 | 81 | 78 | 30 | 53 | 169 | 0 | 0 | 0 | 0 | 11 | 7 | 2 | 4.44 |
| SP | Severino, L.Severino, Luis >> | 24 | 2018 | R | 74 | 25 | 25 | 3 | 10 | 6.36 | .359 | 1.61 | 10.9 | 3.6 | 11.2 | 121.2 | 147 | 89 | 86 | 24 | 49 | 150 | 0 | 0 | 0 | 0 | 9 | 8 | 4 | 4.51 |
| CL | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 98 | 57 | 0 | 2 | 7 | 4.36 | .317 | 1.31 | 6.8 | 5.1 | 11.4 | 64.0 | 48 | 31 | 31 | 11 | 36 | 81 | 0 | 19 | 8 | 0 | 0 | 5 | 4 | 4.63 |
| RP | Jeffress, J.Jeffress, Jeremy >> | 30 | 2018 | R | 91 | 80 | 0 | 4 | 4 | 4.26 | .300 | 1.24 | 7.7 | 3.5 | 11.3 | 82.1 | 70 | 40 | 39 | 10 | 32 | 103 | 0 | 1 | 8 | 0 | 0 | 4 | 3 | 3.39 |
| RP | Hernandez, D.Hernandez, David >> | 33 | 2018 | R | 86 | 66 | 0 | 5 | 4 | 5.06 | .340 | 1.53 | 10.4 | 3.4 | 9.8 | 69.1 | 80 | 41 | 39 | 7 | 26 | 75 | 0 | 2 | 3 | 0 | 0 | 1 | 6 | 3.32 |
| RP | Watson, T.Watson, Tony >> | 33 | 2018 | L | 75 | 92 | 0 | 3 | 3 | 4.26 | .302 | 1.30 | 8.3 | 3.5 | 9.4 | 67.2 | 62 | 37 | 32 | 6 | 26 | 70 | 0 | 1 | 7 | 0 | 0 | 0 | 0 | 3.24 |
| SP | Porcello, R.Porcello, Rick >> | 29 | 2018 | R | 69 | 22 | 0 | 6 | 3 | 3.51 | .313 | 1.32 | 8.3 | 3.5 | 7.5 | 41.0 | 38 | 16 | 16 | 4 | 16 | 34 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 3.93 |