| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 20 | 7 | 3.06 | .260 | 1.03 | 7.2 | 2.1 | 9.2 | 226.1 | 181 | 78 | 77 | 24 | 53 | 232 | 0 | 0 | 0 | 0 | 24 | 5 | 0 | 3.10 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 35 | 33 | 15 | 14 | 4.11 | .298 | 1.25 | 8.4 | 2.9 | 5.5 | 232.0 | 216 | 111 | 106 | 30 | 74 | 141 | 11 | 0 | 0 | 2 | 18 | 6 | 5 | 4.50 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 33 | 33 | 11 | 5 | 4.74 | .351 | 1.59 | 9.4 | 5.0 | 7.8 | 172.2 | 180 | 94 | 91 | 24 | 95 | 149 | 0 | 0 | 0 | 0 | 18 | 5 | 5 | 4.83 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 32 | 32 | 10 | 16 | 5.68 | .342 | 1.54 | 10.0 | 3.9 | 5.4 | 185.1 | 205 | 119 | 117 | 28 | 80 | 111 | 2 | 0 | 0 | 1 | 8 | 4 | 13 | 5.13 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 75 | 0 | 5 | 1 | 3.39 | .229 | 0.88 | 5.3 | 2.7 | 9.0 | 101.0 | 59 | 40 | 38 | 8 | 30 | 101 | 0 | 2 | 2 | 0 | 0 | 1 | 4 | 2.95 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 51 | 0 | 4 | 3 | 4.24 | .317 | 1.40 | 7.7 | 4.9 | 9.5 | 57.1 | 49 | 27 | 27 | 6 | 31 | 60 | 0 | 1 | 5 | 0 | 0 | 0 | 2 | 3.89 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 67 | 0 | 7 | 2 | 2.49 | .289 | 1.22 | 7.7 | 3.3 | 8.7 | 79.2 | 68 | 25 | 22 | 7 | 29 | 76 | 0 | 35 | 3 | 0 | 0 | 0 | 1 | 3.33 |