| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 27 | 27 | 14 | 5 | 3.35 | .290 | 1.19 | 6.9 | 3.8 | 5.1 | 166.2 | 128 | 64 | 62 | 12 | 70 | 94 | 1 | 0 | 0 | 0 | 19 | 6 | 1 | 4.18 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 26 | 26 | 8 | 9 | 5.30 | .327 | 1.42 | 9.8 | 3.0 | 8.8 | 146.0 | 159 | 95 | 86 | 23 | 49 | 142 | 2 | 0 | 0 | 0 | 11 | 5 | 2 | 4.21 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 27 | 25 | 13 | 5 | 3.93 | .313 | 1.36 | 7.9 | 4.4 | 4.3 | 167.1 | 146 | 82 | 73 | 13 | 82 | 79 | 2 | 1 | 0 | 1 | 14 | 1 | 3 | 4.56 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 74 | 0 | 3 | 3 | 3.46 | .304 | 1.28 | 8.0 | 3.6 | 9.7 | 96.1 | 85 | 39 | 37 | 11 | 38 | 103 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 3.63 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 60 | 0 | 7 | 1 | 3.10 | .277 | 1.15 | 8.0 | 2.4 | 7.5 | 78.1 | 69 | 28 | 27 | 10 | 21 | 65 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.81 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 47 | 0 | 3 | 3 | 4.14 | .282 | 1.16 | 7.0 | 3.6 | 10.4 | 58.2 | 45 | 27 | 27 | 6 | 23 | 67 | 0 | 1 | 4 | 0 | 0 | 1 | 5 | 3.28 |
| RP | Wilhelm, H.Wilhelm, Hoyt # >> | 43 | 1965 | R | 68 | 43 | 0 | 3 | 4 | 5.91 | .352 | 1.63 | 11.0 | 3.7 | 3.9 | 53.1 | 65 | 37 | 35 | 7 | 22 | 23 | 0 | 2 | 1 | 0 | 0 | 0 | 5 | 5.09 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 59 | 0 | 4 | 7 | 3.07 | .290 | 1.21 | 6.4 | 4.5 | 9.1 | 70.1 | 50 | 26 | 24 | 6 | 35 | 71 | 0 | 30 | 1 | 0 | 0 | 1 | 4 | 3.63 |