| SP | Greinke, Z.Greinke, Zack † >> | 32 | 2015 | R | 94 | 37 | 37 | 20 | 7 | 3.25 | .276 | 1.13 | 7.7 | 2.4 | 5.4 | 269.0 | 230 | 101 | 97 | 24 | 73 | 162 | 5 | 0 | 0 | 0 | 26 | 5 | 4 | 3.83 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 35 | 35 | 13 | 12 | 3.90 | .271 | 1.11 | 7.1 | 2.9 | 5.6 | 228.2 | 180 | 103 | 99 | 18 | 74 | 142 | 2 | 0 | 0 | 1 | 23 | 1 | 2 | 3.77 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 34 | 34 | 12 | 9 | 3.14 | .267 | 1.08 | 7.6 | 2.1 | 4.8 | 246.2 | 209 | 92 | 86 | 21 | 57 | 132 | 4 | 0 | 0 | 2 | 25 | 4 | 3 | 3.78 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 31 | 31 | 17 | 7 | 3.34 | .273 | 1.11 | 7.4 | 2.6 | 4.3 | 215.1 | 177 | 83 | 80 | 21 | 61 | 103 | 7 | 0 | 0 | 2 | 18 | 4 | 2 | 4.22 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 30 | 30 | 11 | 8 | 4.19 | .313 | 1.34 | 8.1 | 3.9 | 5.2 | 206.1 | 186 | 112 | 96 | 16 | 90 | 120 | 2 | 0 | 0 | 1 | 18 | 6 | 6 | 4.24 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 75 | 0 | 9 | 8 | 2.18 | .230 | 0.88 | 5.7 | 2.3 | 10.0 | 82.2 | 52 | 25 | 20 | 7 | 21 | 91 | 0 | 41 | 6 | 0 | 0 | 1 | 0 | 2.70 |
| SU | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 47 | 0 | 0 | 3 | 3.19 | .301 | 1.25 | 7.7 | 3.6 | 8.4 | 48.0 | 41 | 19 | 17 | 3 | 19 | 45 | 0 | 9 | 6 | 0 | 0 | 2 | 3 | 3.25 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 31 | 41 | 0 | 2 | 6 | 2.83 | .292 | 1.20 | 6.5 | 4.4 | 7.9 | 47.2 | 34 | 16 | 15 | 5 | 23 | 41 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.23 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 29 | 0 | 2 | 2 | 3.58 | .258 | 1.04 | 6.2 | 3.4 | 8.4 | 32.2 | 22 | 14 | 13 | 5 | 12 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.28 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 49 | 1 | 0 | 1 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 4 | 0 | 0 | 1 | 0.00 | .316 | 1.15 | 6.8 | 4.5 | 4.5 | 4.1 | 3 | 2 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.25 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 15 | 2 | 1 | 1 | 2.78 | .272 | 1.09 | 5.5 | 4.4 | 8.2 | 77.2 | 47 | 28 | 24 | 5 | 38 | 70 | 1 | 0 | 0 | 0 | 2 | 2 | 3 | 3.58 |