| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 37 | 37 | 17 | 7 | 2.96 | .304 | 1.30 | 7.1 | 4.7 | 11.3 | 191.2 | 150 | 74 | 63 | 23 | 99 | 239 | 0 | 0 | 0 | 0 | 10 | 2 | 5 | 3.65 |
| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 36 | 36 | 21 | 8 | 3.63 | .275 | 1.11 | 7.7 | 2.3 | 11.0 | 233.1 | 199 | 96 | 94 | 36 | 60 | 284 | 0 | 0 | 0 | 0 | 23 | 6 | 1 | 3.42 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 82 | 34 | 34 | 13 | 8 | 4.63 | .311 | 1.32 | 9.5 | 2.4 | 10.0 | 206.0 | 217 | 113 | 106 | 36 | 55 | 230 | 0 | 0 | 0 | 0 | 15 | 7 | 3 | 3.94 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 64 | 34 | 33 | 5 | 5 | 7.56 | .401 | 1.95 | 11.9 | 5.8 | 10.2 | 116.2 | 153 | 102 | 98 | 33 | 75 | 131 | 0 | 0 | 0 | 0 | 0 | 6 | 3 | 6.53 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 89 | 100 | 0 | 8 | 6 | 4.01 | .298 | 1.23 | 7.3 | 3.7 | 9.3 | 128.0 | 104 | 59 | 57 | 16 | 53 | 132 | 0 | 0 | 1 | 0 | 0 | 6 | 2 | 3.95 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 82 | 87 | 0 | 8 | 1 | 4.15 | .336 | 1.48 | 9.3 | 4.1 | 11.4 | 102.0 | 105 | 50 | 47 | 12 | 46 | 129 | 0 | 2 | 1 | 0 | 0 | 4 | 3 | 3.47 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 86 | 0 | 6 | 7 | 3.07 | .279 | 1.11 | 6.5 | 3.5 | 10.6 | 88.0 | 64 | 31 | 30 | 7 | 34 | 104 | 0 | 39 | 5 | 0 | 0 | 4 | 3 | 2.97 |
| SU | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 92 | 87 | 0 | 5 | 2 | 3.54 | .285 | 1.12 | 7.5 | 2.6 | 9.3 | 104.1 | 87 | 44 | 41 | 16 | 30 | 108 | 0 | 8 | 6 | 0 | 0 | 8 | 0 | 4.02 |