| SP | Peralta, F.Peralta, Freddy † >> | 29 | 2025 | R | 92 | 31 | 31 | 15 | 6 | 2.74 | .277 | 1.11 | 7.0 | 3.0 | 8.3 | 184.0 | 143 | 58 | 56 | 16 | 61 | 170 | 0 | 0 | 0 | 0 | 17 | 7 | 7 | 3.39 |
| SP | Chacin, J.Chacin, Jhoulys # >> | 30 | 2018 | R | 68 | 28 | 28 | 12 | 11 | 4.39 | .301 | 1.28 | 7.5 | 4.0 | 6.4 | 155.2 | 130 | 80 | 76 | 17 | 69 | 110 | 0 | 0 | 0 | 0 | 12 | 2 | 1 | 4.38 |
| SP | Marcum, S.Marcum, Shaun >> | 30 | 2011 | R | 62 | 30 | 30 | 11 | 7 | 4.17 | .306 | 1.29 | 9.0 | 2.7 | 7.0 | 190.0 | 190 | 91 | 88 | 19 | 56 | 147 | 0 | 0 | 0 | 0 | 15 | 5 | 3 | 3.72 |
| SP | Greinke, Z.Greinke, Zack # >> | 28 | 2011 | R | 56 | 30 | 30 | 9 | 11 | 5.23 | .337 | 1.49 | 10.2 | 3.2 | 9.5 | 186.0 | 211 | 111 | 108 | 28 | 67 | 196 | 0 | 0 | 0 | 0 | 12 | 6 | 5 | 4.03 |
| SP | Gallardo, Y.Gallardo, Yovani >> | 25 | 2011 | R | 52 | 12 | 12 | 2 | 5 | 4.98 | .298 | 1.25 | 9.2 | 2.1 | 7.4 | 77.2 | 79 | 46 | 43 | 13 | 18 | 63 | 1 | 0 | 0 | 1 | 6 | 2 | 2 | 4.34 |
| RP | Hader, J.Hader, Josh # >> | 24 | 2018 | L | 100 | 103 | 0 | 3 | 2 | 4.48 | .275 | 1.09 | 5.9 | 4.0 | 9.8 | 70.1 | 46 | 35 | 35 | 10 | 31 | 76 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 4.14 |
| RP | Woodruff, B.Woodruff, Brandon >> | 32 | 2025 | R | 92 | 91 | 0 | 5 | 7 | 4.44 | .335 | 1.50 | 9.7 | 3.8 | 8.7 | 103.1 | 111 | 52 | 51 | 10 | 44 | 99 | 0 | 4 | 6 | 0 | 0 | 1 | 1 | 3.65 |
| RP | Jeffress, J.Jeffress, Jeremy >> | 30 | 2018 | R | 87 | 68 | 0 | 2 | 4 | 3.36 | .295 | 1.24 | 6.6 | 4.6 | 9.5 | 59.0 | 43 | 22 | 22 | 4 | 30 | 62 | 0 | 19 | 1 | 0 | 0 | 1 | 3 | 3.36 |
| RP | Burnes, C.Burnes, Corbin # >> | 23 | 2018 | R | 84 | 62 | 0 | 5 | 4 | 4.70 | .316 | 1.30 | 7.7 | 4.0 | 7.4 | 67.0 | 57 | 35 | 35 | 7 | 30 | 55 | 0 | 3 | 5 | 0 | 0 | 6 | 1 | 4.33 |
| RP | Fingers, R.Fingers, Rollie >> | 36 | 1982 | R | 71 | 39 | 0 | 6 | 1 | 2.51 | .283 | 1.19 | 7.3 | 3.3 | 7.3 | 43.0 | 35 | 12 | 12 | 2 | 16 | 35 | 0 | 5 | 3 | 0 | 0 | 0 | 1 | 3.09 |
| RP | Axford, J.Axford, John >> | 28 | 2011 | R | 67 | 20 | 0 | 0 | 0 | 2.61 | .262 | 1.06 | 4.5 | 5.4 | 6.8 | 20.2 | 10 | 6 | 6 | 3 | 12 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 5.25 |
| RP | Misiorowski, J.Misiorowski, Jacob >> | 23 | 2025 | R | 63 | 7 | 0 | 0 | 1 | 6.00 | .400 | 2.00 | 13.5 | 4.5 | 6.0 | 6.0 | 9 | 4 | 4 | 3 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.67 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 29 | 2011 | R | 45 | 28 | 0 | 1 | 1 | 2.45 | .290 | 1.23 | 7.1 | 4.0 | 8.4 | 29.1 | 23 | 8 | 8 | 3 | 13 | 27 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 3.83 |