| SP | Rodon, C.Rodon, Carlos † >> | 28 | 2021 | L | 98 | 24 | 24 | 17 | 4 | 3.19 | .262 | 1.03 | 6.6 | 2.7 | 8.9 | 172.0 | 126 | 62 | 61 | 16 | 52 | 171 | 3 | 0 | 0 | 0 | 18 | 5 | 2 | 3.22 |
| SP | Smith, F.Smith, Frank # >> | 31 | 1910 | R | 79 | 23 | 23 | 6 | 7 | 5.29 | .339 | 1.50 | 9.1 | 4.4 | 5.7 | 131.0 | 133 | 79 | 77 | 15 | 64 | 83 | 3 | 0 | 0 | 1 | 10 | 5 | 3 | 4.80 |
| RP | Hernandez, R.Hernandez, Roberto >> | 28 | 1992 | R | 86 | 48 | 0 | 4 | 5 | 2.74 | .236 | 0.88 | 5.1 | 2.9 | 7.5 | 65.2 | 37 | 21 | 20 | 6 | 21 | 54 | 0 | 6 | 3 | 0 | 0 | 3 | 0 | 3.65 |
| RP | Hendriks, L.Hendriks, Liam >> | 32 | 2021 | R | 97 | 57 | 0 | 4 | 4 | 2.87 | .272 | 1.07 | 6.9 | 2.9 | 9.5 | 59.2 | 45 | 19 | 19 | 6 | 19 | 62 | 0 | 8 | 3 | 0 | 0 | 3 | 9 | 3.34 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 95 | 44 | 0 | 3 | 1 | 3.98 | .314 | 1.35 | 5.9 | 6.3 | 9.8 | 43.0 | 28 | 19 | 19 | 6 | 30 | 47 | 0 | 5 | 0 | 0 | 0 | 1 | 4 | 4.79 |
| RP | Bummer, A.Bummer, Aaron >> | 27 | 2021 | L | 50 | 64 | 0 | 3 | 0 | 2.78 | .280 | 1.13 | 6.0 | 4.2 | 10.8 | 45.1 | 30 | 16 | 14 | 5 | 21 | 54 | 0 | 5 | 0 | 0 | 0 | 2 | 6 | 3.58 |
| RP | Lopez, R.Lopez, Reynaldo >> | 27 | 2021 | R | 76 | 24 | 0 | 3 | 3 | 5.55 | .367 | 1.74 | 11.6 | 4.4 | 6.4 | 35.2 | 45 | 23 | 22 | 5 | 17 | 25 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 4.89 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 92 | 24 | 0 | 0 | 1 | 6.51 | .341 | 1.55 | 9.3 | 5.0 | 9.3 | 27.2 | 28 | 20 | 20 | 2 | 15 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.56 |