| SP | Pfiester, J.Pfiester, Jack >> | 29 | 1907 | L | 84 | 9 | 9 | 2 | 4 | 2.73 | .277 | 1.15 | 7.4 | 3.0 | 5.4 | 62.2 | 51 | 22 | 19 | 3 | 21 | 37 | 0 | 0 | 0 | 0 | 8 | 0 | 2 | 3.45 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 90 | 8 | 8 | 3 | 3 | 4.09 | .315 | 1.34 | 8.5 | 3.8 | 5.8 | 50.2 | 47 | 23 | 23 | 3 | 21 | 32 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 3.88 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 79 | 8 | 8 | 7 | 0 | 3.21 | .302 | 1.30 | 7.7 | 4.1 | 5.8 | 61.2 | 52 | 23 | 22 | 4 | 28 | 39 | 2 | 0 | 0 | 0 | 5 | 0 | 0 | 3.95 |
| SP | Brown, M.Brown, Mordecai # >> | 31 | 1907 | R | 83 | 8 | 8 | 4 | 2 | 2.91 | .248 | 0.94 | 6.7 | 1.9 | 6.1 | 58.2 | 43 | 19 | 19 | 2 | 12 | 39 | 1 | 0 | 0 | 0 | 6 | 3 | 0 | 2.88 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 85 | 8 | 8 | 5 | 2 | 3.40 | .302 | 1.24 | 7.5 | 3.8 | 8.8 | 47.2 | 39 | 20 | 18 | 6 | 20 | 46 | 0 | 0 | 0 | 0 | 6 | 3 | 3 | 4.17 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 71 | 14 | 0 | 1 | 0 | 3.18 | .346 | 1.41 | 9.8 | 3.3 | 11.5 | 11.1 | 12 | 7 | 4 | 2 | 4 | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.45 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 57 | 15 | 0 | 0 | 0 | 3.57 | .264 | 1.08 | 6.9 | 3.2 | 5.3 | 17.2 | 13 | 7 | 7 | 2 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.41 |
| SU | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 17 | 0 | 0 | 1 | 1.56 | .278 | 0.98 | 5.3 | 3.7 | 8.5 | 17.1 | 10 | 4 | 3 | 0 | 7 | 16 | 0 | 3 | 1 | 0 | 0 | 3 | 2 | 2.88 |
| SP | Overall, O.Overall, Orval >> | 26 | 1907 | R | 82 | 2 | 0 | 0 | 0 | 2.70 | .375 | 1.80 | 12.0 | 6.0 | 3.0 | 3.1 | 4 | 2 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.33 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 99 | 16 | 0 | 2 | 3 | 5.93 | .388 | 1.76 | 8.3 | 8.3 | 11.1 | 13.2 | 12 | 9 | 9 | 2 | 12 | 16 | 0 | 6 | 1 | 0 | 0 | 2 | 1 | 5.77 |
| SP | Reulbach, E.Reulbach, Ed >> | 25 | 1907 | R | 72 | 3 | 0 | 0 | 0 | 20.25 | .600 | 4.50 | 45.0 | 9.0 | 0.0 | 1.1 | 5 | 3 | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 19.00 |