| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 90 | 25 | 25 | 12 | 9 | 2.86 | .264 | 1.06 | 7.9 | 1.7 | 5.0 | 189.0 | 165 | 77 | 60 | 15 | 35 | 105 | 7 | 0 | 0 | 1 | 20 | 3 | 4 | 3.52 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 87 | 24 | 24 | 12 | 7 | 4.49 | .337 | 1.51 | 10.3 | 3.4 | 7.4 | 134.1 | 153 | 89 | 67 | 15 | 50 | 110 | 0 | 0 | 0 | 0 | 14 | 2 | 3 | 3.98 |
| SP | Overall, O.Overall, Orval # >> | 27 | 1908 | R | 78 | 23 | 23 | 9 | 7 | 4.41 | .289 | 1.19 | 8.4 | 2.3 | 5.8 | 145.0 | 135 | 76 | 71 | 27 | 37 | 94 | 1 | 0 | 0 | 0 | 13 | 5 | 4 | 4.99 |
| SP | Reulbach, E.Reulbach, Ed >> | 26 | 1908 | R | 66 | 16 | 16 | 8 | 4 | 4.70 | .357 | 1.63 | 9.7 | 5.1 | 5.7 | 95.2 | 102 | 61 | 50 | 11 | 54 | 60 | 0 | 0 | 0 | 0 | 9 | 3 | 1 | 5.04 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 66 | 53 | 0 | 3 | 2 | 4.33 | .279 | 1.14 | 7.8 | 2.6 | 7.8 | 60.1 | 52 | 32 | 29 | 10 | 17 | 52 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 4.33 |
| RP | Grimm, J.Grimm, Justin >> | 27 | 2016 | R | 33 | 40 | 0 | 3 | 1 | 5.75 | .344 | 1.55 | 10.1 | 4.1 | 9.2 | 40.2 | 45 | 33 | 26 | 7 | 18 | 41 | 0 | 1 | 1 | 0 | 0 | 1 | 6 | 4.65 |
| CL | Chapman, A.Chapman, Aroldis † >> | 28 | 2016 | L | 98 | 56 | 0 | 7 | 6 | 3.32 | .295 | 1.22 | 6.3 | 4.9 | 11.7 | 59.2 | 41 | 28 | 22 | 6 | 32 | 77 | 0 | 23 | 5 | 0 | 0 | 2 | 10 | 3.44 |
| SU | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 53 | 0 | 2 | 3 | 3.46 | .268 | 1.06 | 5.3 | 4.3 | 7.7 | 54.2 | 32 | 21 | 21 | 5 | 26 | 46 | 0 | 5 | 5 | 0 | 0 | 2 | 3 | 4.06 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 82 | 4 | 0 | 0 | 0 | 7.36 | .290 | 1.23 | 11.6 | 0.0 | 9.0 | 7.1 | 9 | 6 | 6 | 3 | 0 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.57 |
| SP | Pfiester, J.Pfiester, Jack >> | 30 | 1908 | L | 69 | 21 | 7 | 3 | 4 | 3.93 | .293 | 1.21 | 7.2 | 3.8 | 4.9 | 73.1 | 58 | 34 | 32 | 13 | 31 | 40 | 1 | 4 | 1 | 0 | 3 | 2 | 0 | 5.58 |