| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 93 | 31 | 31 | 15 | 10 | 2.77 | .277 | 1.12 | 7.5 | 2.5 | 5.6 | 227.2 | 190 | 89 | 70 | 26 | 64 | 140 | 5 | 0 | 0 | 1 | 22 | 8 | 5 | 4.21 |
| SP | Arrieta, J.Arrieta, Jake # >> | 30 | 2016 | R | 89 | 30 | 30 | 12 | 11 | 3.82 | .297 | 1.24 | 8.3 | 3.0 | 8.8 | 195.2 | 179 | 99 | 83 | 24 | 64 | 190 | 2 | 0 | 0 | 1 | 20 | 5 | 7 | 3.71 |
| SP | Overall, O.Overall, Orval >> | 27 | 1908 | R | 86 | 30 | 30 | 9 | 9 | 2.94 | .296 | 1.23 | 7.8 | 3.3 | 6.3 | 189.2 | 163 | 79 | 62 | 11 | 70 | 133 | 0 | 0 | 0 | 0 | 20 | 6 | 2 | 3.56 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 94 | 30 | 30 | 15 | 8 | 3.11 | .294 | 1.22 | 7.8 | 3.2 | 6.5 | 202.1 | 176 | 76 | 70 | 18 | 71 | 147 | 1 | 0 | 0 | 0 | 21 | 6 | 1 | 3.85 |
| SP | Pfiester, J.Pfiester, Jack # >> | 30 | 1908 | L | 72 | 30 | 30 | 8 | 13 | 4.70 | .324 | 1.38 | 9.6 | 2.9 | 5.5 | 197.1 | 210 | 123 | 103 | 28 | 63 | 121 | 8 | 0 | 0 | 2 | 13 | 11 | 4 | 4.75 |
| RP | Muffett, B.Muffett, Billy >> | 27 | 1957 | R | 66 | 52 | 0 | 9 | 1 | 3.72 | .301 | 1.25 | 7.6 | 3.7 | 5.3 | 75.0 | 63 | 41 | 31 | 6 | 31 | 44 | 0 | 2 | 2 | 0 | 0 | 3 | 5 | 4.23 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 79 | 67 | 0 | 2 | 3 | 4.31 | .307 | 1.31 | 9.3 | 2.7 | 9.0 | 64.2 | 66 | 39 | 31 | 13 | 19 | 64 | 0 | 4 | 1 | 0 | 0 | 1 | 2 | 4.58 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 98 | 64 | 0 | 6 | 9 | 3.82 | .312 | 1.30 | 6.9 | 4.9 | 8.2 | 68.1 | 52 | 38 | 29 | 2 | 37 | 62 | 0 | 24 | 6 | 0 | 0 | 4 | 4 | 3.37 |
| SP | Reulbach, E.Reulbach, Ed >> | 26 | 1908 | R | 71 | 22 | 0 | 1 | 3 | 8.06 | .398 | 1.95 | 12.6 | 5.4 | 4.3 | 25.2 | 35 | 30 | 23 | 4 | 15 | 12 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 6.04 |
| SU | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 72 | 0 | 4 | 1 | 2.27 | .273 | 1.08 | 4.8 | 5.0 | 9.8 | 83.1 | 44 | 23 | 21 | 5 | 46 | 90 | 0 | 3 | 4 | 0 | 0 | 4 | 5 | 3.42 |