| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 24 | 24 | 8 | 8 | 3.26 | .288 | 1.18 | 8.0 | 2.7 | 8.9 | 149.0 | 132 | 62 | 54 | 18 | 44 | 147 | 0 | 0 | 0 | 0 | 17 | 5 | 0 | 3.58 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 22 | 22 | 9 | 7 | 2.60 | .283 | 1.17 | 6.9 | 3.6 | 3.9 | 149.0 | 114 | 59 | 43 | 7 | 60 | 64 | 2 | 0 | 0 | 2 | 15 | 2 | 4 | 4.00 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 10 | 8 | 3 | 5 | 5.34 | .286 | 1.15 | 8.7 | 1.8 | 6.9 | 55.2 | 53 | 33 | 33 | 7 | 11 | 42 | 3 | 0 | 0 | 0 | 3 | 3 | 2 | 3.89 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 22 | 22 | 6 | 4 | 3.99 | .326 | 1.43 | 8.6 | 4.4 | 5.2 | 146.2 | 139 | 76 | 65 | 9 | 71 | 85 | 0 | 0 | 0 | 0 | 16 | 3 | 7 | 4.16 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 61 | 0 | 3 | 3 | 2.05 | .217 | 0.83 | 6.3 | 1.2 | 7.9 | 66.0 | 46 | 18 | 15 | 6 | 9 | 58 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 2.83 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 42 | 0 | 6 | 2 | 2.41 | .263 | 1.07 | 6.3 | 3.4 | 9.5 | 37.1 | 26 | 10 | 10 | 1 | 14 | 39 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 2.38 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 33 | 0 | 1 | 2 | 5.47 | .408 | 2.03 | 10.5 | 8.3 | 7.5 | 24.2 | 28 | 16 | 15 | 2 | 22 | 20 | 0 | 0 | 2 | 0 | 0 | 1 | 6 | 5.29 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 43 | 0 | 5 | 7 | 2.54 | .254 | 1.02 | 5.5 | 3.7 | 6.1 | 46.0 | 28 | 14 | 13 | 4 | 19 | 31 | 0 | 20 | 2 | 0 | 0 | 0 | 1 | 4.02 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 29 | 0 | 0 | 1 | 6.14 | .463 | 2.45 | 14.1 | 9.0 | 8.4 | 14.2 | 22 | 10 | 10 | 4 | 14 | 13 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 8.29 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 17 | 15 | 4 | 4 | 4.98 | .337 | 1.50 | 8.2 | 5.3 | 8.1 | 103.0 | 94 | 64 | 57 | 11 | 61 | 93 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 4.42 |