| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 93 | 35 | 35 | 13 | 11 | 3.92 | .267 | 1.08 | 7.5 | 2.2 | 7.2 | 234.1 | 194 | 103 | 102 | 23 | 58 | 188 | 8 | 0 | 0 | 0 | 19 | 4 | 6 | 3.47 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 34 | 34 | 12 | 10 | 4.58 | .300 | 1.28 | 7.7 | 3.8 | 7.4 | 194.2 | 167 | 99 | 99 | 20 | 82 | 159 | 1 | 0 | 0 | 0 | 19 | 1 | 2 | 3.98 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 33 | 33 | 12 | 13 | 4.38 | .301 | 1.28 | 8.3 | 3.2 | 4.2 | 228.0 | 211 | 118 | 111 | 28 | 80 | 106 | 10 | 0 | 0 | 0 | 16 | 3 | 4 | 4.76 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 81 | 0 | 4 | 4 | 2.15 | .260 | 1.03 | 5.6 | 3.7 | 9.7 | 121.1 | 75 | 33 | 29 | 6 | 50 | 131 | 0 | 14 | 2 | 0 | 0 | 3 | 0 | 2.79 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 62 | 0 | 6 | 4 | 2.70 | .271 | 1.10 | 5.7 | 4.2 | 9.1 | 80.0 | 51 | 25 | 24 | 8 | 37 | 81 | 0 | 8 | 1 | 0 | 0 | 1 | 5 | 3.70 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 46 | 0 | 4 | 2 | 1.92 | .246 | 0.94 | 5.8 | 2.7 | 8.2 | 56.1 | 36 | 14 | 12 | 1 | 17 | 51 | 0 | 8 | 2 | 0 | 0 | 2 | 5 | 2.43 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 33 | 0 | 2 | 2 | 1.23 | .236 | 0.90 | 4.0 | 4.3 | 8.8 | 36.2 | 16 | 5 | 5 | 2 | 17 | 35 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.28 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 29 | 0 | 1 | 4 | 3.89 | .288 | 1.18 | 5.8 | 5.0 | 9.0 | 34.2 | 22 | 17 | 15 | 3 | 19 | 34 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.91 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 29 | 0 | 8 | 4 | 3.86 | .307 | 1.32 | 7.2 | 4.8 | 7.1 | 130.2 | 104 | 59 | 56 | 13 | 69 | 103 | 0 | 0 | 0 | 0 | 0 | 1 | 8 | 4.33 |