| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 32 | 32 | 13 | 10 | 3.48 | .280 | 1.14 | 8.1 | 2.2 | 8.6 | 227.1 | 204 | 102 | 88 | 26 | 56 | 216 | 4 | 0 | 0 | 0 | 24 | 5 | 7 | 3.39 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 31 | 31 | 5 | 15 | 4.94 | .348 | 1.58 | 9.5 | 4.7 | 9.2 | 184.0 | 195 | 121 | 101 | 25 | 96 | 189 | 0 | 0 | 0 | 0 | 13 | 4 | 4 | 4.34 |
| SP | Greinke, Z.Greinke, Zack # >> | 32 | 2015 | R | 94 | 30 | 30 | 8 | 17 | 4.03 | .295 | 1.22 | 9.0 | 2.0 | 5.9 | 205.2 | 204 | 120 | 92 | 30 | 46 | 134 | 3 | 0 | 0 | 1 | 20 | 8 | 7 | 4.39 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 29 | 29 | 12 | 11 | 3.91 | .305 | 1.30 | 8.2 | 3.5 | 4.2 | 209.1 | 191 | 105 | 91 | 25 | 81 | 98 | 6 | 0 | 0 | 1 | 17 | 3 | 3 | 4.82 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 79 | 0 | 3 | 6 | 3.55 | .288 | 1.20 | 7.8 | 3.0 | 11.8 | 101.1 | 88 | 50 | 40 | 13 | 34 | 132 | 0 | 6 | 4 | 0 | 0 | 1 | 9 | 3.10 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 68 | 0 | 4 | 4 | 2.30 | .252 | 1.00 | 6.2 | 2.8 | 9.5 | 86.0 | 59 | 25 | 22 | 8 | 27 | 91 | 0 | 9 | 0 | 0 | 0 | 1 | 3 | 3.07 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 52 | 0 | 0 | 10 | 2.72 | .319 | 1.38 | 7.2 | 5.3 | 8.7 | 56.1 | 45 | 26 | 17 | 7 | 33 | 54 | 0 | 5 | 4 | 0 | 0 | 1 | 1 | 4.52 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 25 | 0 | 0 | 3 | 4.50 | .291 | 1.23 | 9.0 | 2.1 | 9.6 | 30.0 | 30 | 19 | 15 | 6 | 7 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.17 |