| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 32 | 32 | 15 | 10 | 3.15 | .239 | 0.92 | 6.4 | 1.9 | 8.8 | 220.1 | 156 | 81 | 77 | 19 | 47 | 216 | 4 | 0 | 0 | 1 | 20 | 5 | 0 | 2.87 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 31 | 31 | 18 | 8 | 2.95 | .253 | 1.00 | 7.0 | 2.0 | 4.8 | 241.0 | 187 | 85 | 79 | 14 | 53 | 128 | 11 | 0 | 0 | 4 | 22 | 5 | 1 | 3.41 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 30 | 30 | 16 | 9 | 2.81 | .247 | 0.97 | 7.0 | 1.7 | 4.0 | 227.1 | 177 | 76 | 71 | 16 | 43 | 102 | 10 | 0 | 0 | 2 | 21 | 4 | 7 | 3.64 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 30 | 30 | 16 | 11 | 3.76 | .302 | 1.28 | 9.3 | 2.3 | 4.9 | 215.2 | 221 | 97 | 90 | 36 | 55 | 118 | 2 | 0 | 0 | 1 | 17 | 4 | 1 | 4.90 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 30 | 29 | 11 | 9 | 5.09 | .317 | 1.37 | 7.5 | 4.8 | 8.3 | 173.1 | 145 | 100 | 98 | 22 | 92 | 159 | 0 | 0 | 0 | 0 | 15 | 4 | 13 | 4.48 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 73 | 0 | 4 | 3 | 1.96 | .274 | 1.12 | 5.4 | 4.7 | 9.0 | 91.2 | 55 | 22 | 20 | 6 | 48 | 91 | 0 | 3 | 3 | 0 | 0 | 1 | 1 | 3.47 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 48 | 0 | 7 | 1 | 2.76 | .251 | 1.01 | 5.1 | 4.0 | 10.1 | 58.2 | 33 | 18 | 18 | 2 | 26 | 65 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.55 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 31 | 0 | 1 | 2 | 4.13 | .269 | 1.07 | 6.8 | 3.1 | 10.4 | 32.2 | 24 | 15 | 15 | 3 | 11 | 37 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.03 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 31 | 0 | 2 | 0 | 1.73 | .256 | 0.98 | 5.9 | 3.1 | 9.0 | 41.2 | 27 | 8 | 8 | 2 | 14 | 41 | 0 | 1 | 0 | 0 | 0 | 2 | 4 | 2.80 |
| CL | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 67 | 0 | 3 | 6 | 2.78 | .277 | 1.15 | 6.5 | 3.8 | 8.5 | 68.0 | 49 | 21 | 21 | 6 | 29 | 64 | 0 | 41 | 3 | 0 | 0 | 0 | 3 | 3.54 |