| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 97 | 34 | 34 | 17 | 11 | 3.89 | .290 | 1.20 | 7.5 | 3.3 | 9.5 | 229.0 | 190 | 103 | 99 | 34 | 85 | 241 | 2 | 0 | 0 | 1 | 22 | 6 | 5 | 4.02 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 72 | 33 | 33 | 11 | 16 | 4.99 | .335 | 1.49 | 9.6 | 3.8 | 6.9 | 202.0 | 215 | 123 | 112 | 34 | 85 | 154 | 2 | 0 | 0 | 0 | 15 | 5 | 6 | 5.00 |
| SP | Higuera, T.Higuera, Teddy # >> | 30 | 1988 | L | 65 | 32 | 32 | 11 | 12 | 4.88 | .333 | 1.47 | 9.7 | 3.6 | 6.9 | 219.2 | 235 | 133 | 119 | 37 | 87 | 169 | 2 | 0 | 0 | 1 | 15 | 7 | 0 | 4.94 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 58 | 32 | 32 | 6 | 22 | 7.09 | .352 | 1.62 | 10.9 | 3.6 | 7.5 | 185.1 | 225 | 151 | 146 | 42 | 75 | 155 | 0 | 0 | 0 | 0 | 10 | 2 | 6 | 5.52 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 57 | 31 | 31 | 13 | 15 | 4.73 | .305 | 1.31 | 9.6 | 2.1 | 6.2 | 236.0 | 252 | 133 | 124 | 43 | 56 | 163 | 9 | 0 | 0 | 2 | 13 | 3 | 4 | 4.74 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 89 | 0 | 4 | 3 | 2.43 | .267 | 1.08 | 6.4 | 3.4 | 11.0 | 114.2 | 81 | 33 | 31 | 10 | 43 | 139 | 0 | 10 | 1 | 0 | 0 | 1 | 2 | 2.86 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 69 | 72 | 0 | 2 | 4 | 4.11 | .308 | 1.29 | 6.6 | 5.1 | 11.0 | 85.1 | 62 | 40 | 39 | 8 | 48 | 104 | 0 | 10 | 3 | 0 | 0 | 4 | 2 | 3.61 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 52 | 34 | 0 | 2 | 1 | 6.25 | .375 | 1.77 | 8.4 | 7.8 | 8.4 | 31.2 | 29 | 22 | 22 | 4 | 27 | 29 | 0 | 2 | 2 | 0 | 0 | 1 | 4 | 5.52 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 57 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 49 | 11 | 0 | 6 | 0 | 3.51 | .294 | 1.25 | 9.4 | 2.2 | 7.9 | 25.2 | 26 | 10 | 10 | 3 | 6 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.52 |