| SP | Verlander, J.Verlander, Justin $$ >> | 36 | 2019 | R | 99 | 37 | 37 | 16 | 9 | 4.17 | .294 | 1.23 | 7.9 | 3.2 | 10.6 | 213.2 | 186 | 101 | 99 | 37 | 76 | 251 | 3 | 0 | 0 | 0 | 20 | 5 | 3 | 4.04 |
| SP | Santana, J.Santana, Johan $$ >> | 25 | 2004 | L | 91 | 36 | 36 | 18 | 8 | 3.78 | .299 | 1.27 | 8.3 | 3.1 | 9.0 | 226.1 | 208 | 97 | 95 | 30 | 79 | 227 | 3 | 0 | 0 | 1 | 21 | 2 | 5 | 3.79 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 84 | 35 | 35 | 14 | 13 | 5.00 | .329 | 1.43 | 9.0 | 3.8 | 7.1 | 209.0 | 210 | 124 | 116 | 43 | 89 | 165 | 0 | 0 | 0 | 0 | 14 | 8 | 3 | 5.49 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 78 | 34 | 33 | 13 | 15 | 5.10 | .317 | 1.36 | 9.5 | 2.8 | 8.5 | 190.2 | 200 | 110 | 108 | 37 | 60 | 179 | 2 | 0 | 0 | 1 | 14 | 5 | 5 | 4.67 |
| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 65 | 32 | 31 | 12 | 9 | 6.11 | .347 | 1.59 | 11.6 | 2.7 | 9.8 | 175.1 | 226 | 125 | 119 | 33 | 52 | 191 | 2 | 0 | 0 | 0 | 12 | 2 | 5 | 4.19 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 86 | 0 | 9 | 3 | 3.20 | .238 | 0.91 | 6.6 | 1.6 | 9.9 | 107.0 | 78 | 38 | 38 | 10 | 19 | 118 | 0 | 3 | 1 | 0 | 0 | 3 | 0 | 2.63 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 66 | 0 | 3 | 0 | 3.79 | .266 | 1.07 | 7.3 | 2.4 | 9.5 | 78.1 | 63 | 35 | 33 | 9 | 21 | 82 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.24 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 81 | 40 | 0 | 4 | 1 | 5.01 | .271 | 1.11 | 6.4 | 3.7 | 11.2 | 41.1 | 29 | 23 | 23 | 9 | 17 | 51 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.61 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 26 | 0 | 1 | 1 | 2.05 | .270 | 1.11 | 7.2 | 3.0 | 6.0 | 30.2 | 24 | 7 | 7 | 2 | 10 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.53 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 17 | 0 | 2 | 0 | 4.34 | .325 | 1.39 | 8.5 | 4.5 | 11.5 | 18.2 | 17 | 9 | 9 | 3 | 9 | 23 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.28 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 31 | 0 | 0 | 0 | 4.46 | .286 | 1.10 | 6.9 | 3.1 | 10.9 | 38.1 | 29 | 19 | 19 | 9 | 13 | 46 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 5.00 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 58 | 0 | 4 | 7 | 3.02 | .287 | 1.19 | 8.2 | 2.6 | 10.5 | 59.2 | 54 | 20 | 20 | 4 | 17 | 69 | 0 | 36 | 4 | 0 | 0 | 1 | 0 | 2.46 |
| SU | Chapman, A.Chapman, Aroldis >> | 24 | 2012 | L | 88 | 64 | 0 | 0 | 5 | 3.63 | .276 | 1.12 | 6.4 | 3.6 | 10.6 | 74.1 | 53 | 31 | 30 | 9 | 30 | 87 | 0 | 7 | 7 | 0 | 0 | 2 | 4 | 3.53 |