| SP | Scherzer, M.Scherzer, Max $ >> | 33 | 2017 | R | 97 | 33 | 33 | 17 | 11 | 4.23 | .312 | 1.35 | 8.0 | 4.2 | 9.1 | 206.1 | 182 | 97 | 97 | 27 | 96 | 209 | 1 | 0 | 0 | 0 | 19 | 3 | 10 | 4.12 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 32 | 32 | 9 | 11 | 5.36 | .324 | 1.43 | 9.5 | 3.3 | 8.6 | 188.0 | 199 | 118 | 112 | 41 | 69 | 180 | 0 | 0 | 0 | 0 | 15 | 2 | 6 | 5.05 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 85 | 32 | 32 | 7 | 14 | 5.82 | .353 | 1.58 | 11.1 | 3.2 | 9.1 | 171.2 | 211 | 113 | 111 | 24 | 61 | 173 | 1 | 0 | 0 | 1 | 9 | 9 | 1 | 4.03 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 77 | 32 | 32 | 12 | 14 | 4.84 | .326 | 1.41 | 9.2 | 3.5 | 9.0 | 191.1 | 195 | 111 | 103 | 30 | 74 | 191 | 3 | 0 | 0 | 2 | 16 | 9 | 1 | 4.35 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 32 | 30 | 6 | 15 | 6.82 | .344 | 1.56 | 10.2 | 3.9 | 6.6 | 163.2 | 185 | 124 | 124 | 36 | 71 | 119 | 0 | 0 | 0 | 0 | 9 | 2 | 5 | 5.75 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 71 | 0 | 7 | 6 | 2.49 | .260 | 1.04 | 5.6 | 3.8 | 8.3 | 76.0 | 47 | 23 | 21 | 3 | 32 | 70 | 0 | 44 | 4 | 0 | 0 | 1 | 1 | 2.97 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 60 | 0 | 2 | 2 | 3.61 | .320 | 1.36 | 7.1 | 5.2 | 12.0 | 57.1 | 45 | 24 | 23 | 5 | 33 | 76 | 0 | 4 | 4 | 0 | 0 | 3 | 0 | 3.37 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 82 | 82 | 0 | 9 | 0 | 4.16 | .318 | 1.38 | 8.6 | 3.8 | 9.5 | 110.1 | 105 | 52 | 51 | 26 | 47 | 116 | 0 | 1 | 4 | 0 | 0 | 2 | 0 | 5.30 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 68 | 0 | 6 | 2 | 4.46 | .307 | 1.27 | 7.8 | 3.7 | 9.6 | 70.2 | 61 | 39 | 35 | 7 | 29 | 75 | 0 | 1 | 1 | 0 | 0 | 4 | 4 | 3.57 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 47 | 0 | 3 | 2 | 3.04 | .310 | 1.35 | 7.5 | 4.8 | 9.5 | 53.1 | 44 | 18 | 18 | 5 | 28 | 56 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.70 |