| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 98 | 33 | 33 | 17 | 14 | 3.24 | .278 | 1.14 | 8.3 | 2.0 | 10.1 | 249.2 | 230 | 94 | 90 | 29 | 55 | 280 | 8 | 0 | 0 | 2 | 22 | 4 | 6 | 2.98 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 67 | 31 | 31 | 13 | 8 | 3.90 | .285 | 1.18 | 6.3 | 4.4 | 9.1 | 203.1 | 141 | 89 | 88 | 22 | 99 | 206 | 0 | 0 | 0 | 0 | 16 | 3 | 4 | 3.89 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 32 | 32 | 11 | 15 | 4.49 | .322 | 1.39 | 9.5 | 3.0 | 6.3 | 226.1 | 239 | 123 | 113 | 38 | 76 | 157 | 6 | 0 | 0 | 1 | 13 | 7 | 7 | 4.90 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 69 | 30 | 30 | 12 | 15 | 4.02 | .309 | 1.32 | 8.0 | 3.9 | 6.1 | 219.1 | 195 | 100 | 98 | 26 | 94 | 148 | 9 | 0 | 0 | 3 | 15 | 5 | 6 | 4.55 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 85 | 0 | 5 | 6 | 3.31 | .253 | 0.99 | 6.4 | 2.5 | 9.4 | 122.1 | 87 | 45 | 45 | 17 | 34 | 127 | 0 | 13 | 2 | 0 | 0 | 3 | 0 | 3.64 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 79 | 60 | 0 | 6 | 1 | 2.27 | .281 | 1.17 | 7.3 | 3.4 | 9.1 | 67.1 | 54 | 19 | 17 | 5 | 25 | 68 | 0 | 6 | 3 | 0 | 0 | 0 | 1 | 3.06 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 39 | 0 | 2 | 2 | 3.11 | .257 | 1.01 | 7.2 | 2.0 | 9.2 | 46.1 | 37 | 16 | 16 | 10 | 10 | 47 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 4.50 |
| RP | Benitez, A.Benitez, Armando >> | 27 | 1999 | R | 57 | 31 | 0 | 1 | 1 | 1.91 | .233 | 0.88 | 3.3 | 4.6 | 12.0 | 33.0 | 12 | 8 | 7 | 0 | 17 | 44 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 1.97 |
| SP | Messersmith, A.Messersmith, Andy >> | 30 | 1975 | R | 42 | 5 | 5 | 1 | 1 | 7.16 | .381 | 1.81 | 12.0 | 4.7 | 4.0 | 27.2 | 36 | 24 | 22 | 7 | 14 | 12 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 7.15 |