| SP | Koufax, S.Koufax, Sandy # $ >> | 30 | 1965 | L | 97 | 29 | 29 | 7 | 10 | 5.00 | .322 | 1.41 | 9.6 | 3.1 | 7.4 | 172.2 | 184 | 103 | 96 | 19 | 60 | 142 | 4 | 0 | 0 | 1 | 12 | 2 | 2 | 3.87 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 28 | 28 | 15 | 5 | 3.57 | .286 | 1.18 | 9.0 | 1.6 | 4.1 | 191.1 | 191 | 80 | 76 | 8 | 35 | 88 | 8 | 0 | 0 | 1 | 18 | 4 | 2 | 3.24 |
| SP | Brown, M.Brown, Mordecai # $ >> | 32 | 1908 | R | 85 | 28 | 28 | 17 | 9 | 3.48 | .282 | 1.15 | 8.4 | 2.0 | 4.0 | 199.1 | 185 | 81 | 77 | 19 | 45 | 88 | 5 | 0 | 0 | 0 | 17 | 5 | 0 | 4.11 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 81 | 27 | 27 | 8 | 10 | 4.06 | .308 | 1.33 | 7.8 | 4.2 | 7.6 | 155.0 | 134 | 71 | 70 | 18 | 72 | 131 | 0 | 0 | 0 | 0 | 14 | 1 | 4 | 4.23 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 70 | 0 | 5 | 2 | 2.73 | .250 | 0.99 | 6.2 | 2.7 | 8.1 | 89.0 | 61 | 27 | 27 | 11 | 27 | 80 | 0 | 10 | 1 | 0 | 0 | 1 | 0 | 3.75 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 30 | 0 | 2 | 1 | 2.59 | .293 | 1.15 | 7.0 | 3.5 | 9.3 | 31.1 | 24 | 10 | 9 | 1 | 12 | 32 | 0 | 4 | 2 | 0 | 0 | 3 | 0 | 2.81 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 19 | 0 | 1 | 0 | 3.05 | .244 | 0.97 | 5.4 | 3.6 | 8.6 | 20.2 | 12 | 9 | 7 | 1 | 8 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.95 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 19 | 0 | 0 | 1 | 3.51 | .252 | 0.97 | 7.6 | 1.4 | 10.8 | 25.2 | 21 | 10 | 10 | 4 | 4 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.28 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 54 | 0 | 2 | 7 | 3.91 | .289 | 1.19 | 7.2 | 3.5 | 9.9 | 69.0 | 55 | 31 | 30 | 6 | 27 | 76 | 0 | 18 | 3 | 0 | 0 | 2 | 1 | 3.19 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 16 | 0 | 3 | 0 | 3.77 | .309 | 1.32 | 7.9 | 4.1 | 4.9 | 59.2 | 52 | 25 | 25 | 7 | 27 | 32 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.88 |