| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 24 | 24 | 12 | 5 | 4.02 | .282 | 1.14 | 8.5 | 1.7 | 4.7 | 170.0 | 160 | 77 | 76 | 25 | 33 | 88 | 5 | 0 | 0 | 1 | 12 | 7 | 0 | 4.58 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 23 | 23 | 5 | 13 | 6.29 | .357 | 1.64 | 10.9 | 3.9 | 5.0 | 140.1 | 169 | 109 | 98 | 18 | 61 | 77 | 2 | 0 | 0 | 0 | 8 | 4 | 3 | 4.96 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 22 | 22 | 7 | 7 | 5.56 | .346 | 1.55 | 10.0 | 4.0 | 3.4 | 123.0 | 137 | 85 | 76 | 16 | 54 | 46 | 0 | 0 | 0 | 0 | 11 | 4 | 1 | 5.36 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 63 | 0 | 7 | 4 | 2.95 | .261 | 1.02 | 6.2 | 3.1 | 8.7 | 106.2 | 73 | 35 | 35 | 8 | 36 | 103 | 0 | 11 | 2 | 0 | 0 | 4 | 0 | 3.17 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 56 | 0 | 6 | 2 | 4.04 | .284 | 1.18 | 6.7 | 3.9 | 5.5 | 71.1 | 53 | 33 | 32 | 7 | 31 | 43 | 0 | 10 | 3 | 0 | 0 | 1 | 0 | 4.42 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 42 | 0 | 4 | 2 | 2.27 | .300 | 1.29 | 6.5 | 5.3 | 9.5 | 39.2 | 28 | 11 | 10 | 3 | 23 | 41 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 3.67 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 38 | 0 | 1 | 5 | 5.82 | .348 | 1.57 | 8.6 | 5.6 | 6.6 | 68.0 | 65 | 45 | 44 | 7 | 42 | 50 | 0 | 4 | 1 | 0 | 0 | 2 | 6 | 4.81 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 3 | 0 | 0 | 0 | 1.69 | .158 | 0.56 | 5.4 | 0.0 | 1.8 | 5.1 | 3 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.20 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 19 | 0 | 2 | 3 | 7.76 | .369 | 1.76 | 11.9 | 4.1 | 5.2 | 31.1 | 41 | 29 | 27 | 5 | 14 | 18 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 5.29 |