| SP | Arrieta, J.Arrieta, Jake $$ >> | 29 | 2015 | R | 92 | 28 | 28 | 8 | 9 | 4.96 | .332 | 1.46 | 9.7 | 3.5 | 7.0 | 168.2 | 181 | 98 | 93 | 15 | 66 | 130 | 2 | 0 | 0 | 0 | 14 | 4 | 5 | 3.86 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 28 | 28 | 14 | 7 | 3.63 | .277 | 1.12 | 8.2 | 2.0 | 5.1 | 188.2 | 171 | 89 | 76 | 17 | 41 | 107 | 1 | 0 | 0 | 1 | 17 | 5 | 0 | 3.77 |
| SP | Fernandez, S.Fernandez, Sid † $$ >> | 23 | 1985 | L | 49 | 28 | 27 | 20 | 3 | 2.27 | .268 | 1.10 | 6.3 | 3.7 | 7.6 | 182.2 | 127 | 47 | 46 | 5 | 74 | 153 | 2 | 0 | 0 | 2 | 22 | 0 | 2 | 2.90 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 53 | 0 | 3 | 6 | 2.34 | .258 | 1.02 | 5.8 | 3.5 | 7.3 | 57.2 | 37 | 16 | 15 | 4 | 22 | 46 | 0 | 31 | 2 | 0 | 0 | 1 | 1 | 3.51 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 59 | 0 | 1 | 4 | 3.03 | .267 | 1.06 | 4.9 | 4.7 | 8.4 | 59.1 | 32 | 20 | 20 | 2 | 31 | 55 | 0 | 6 | 5 | 0 | 0 | 2 | 0 | 3.25 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 40 | 0 | 3 | 1 | 2.27 | .235 | 0.88 | 4.6 | 3.4 | 10.5 | 47.2 | 24 | 12 | 12 | 3 | 18 | 55 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 2.77 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 27 | 0 | 2 | 3 | 6.75 | .372 | 1.70 | 8.6 | 6.8 | 6.8 | 25.1 | 24 | 19 | 19 | 4 | 19 | 19 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 6.08 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 15 | 0 | 1 | 0 | 2.87 | .288 | 1.21 | 6.0 | 5.4 | 9.0 | 15.2 | 10 | 5 | 5 | 2 | 9 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.53 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 8 | 0 | 1 | 0 | 2.35 | .303 | 1.30 | 6.4 | 6.4 | 11.6 | 7.2 | 5 | 2 | 2 | 2 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.29 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 69 | 11 | 0 | 0 | 0 | 2.57 | .300 | 1.29 | 8.4 | 3.2 | 5.8 | 14.0 | 13 | 4 | 4 | 2 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.64 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 21 | 0 | 5 | 0 | 2.62 | .243 | 0.93 | 5.3 | 3.2 | 7.9 | 34.1 | 20 | 10 | 10 | 5 | 12 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.29 |