| SP | Martinez, P.Martinez, Pedro † # >> | 29 | 2000 | R | 100 | 20 | 20 | 11 | 5 | 3.45 | .276 | 1.13 | 8.3 | 2.0 | 7.6 | 138.1 | 127 | 56 | 53 | 16 | 30 | 116 | 6 | 0 | 0 | 2 | 12 | 1 | 2 | 3.50 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 20 | 19 | 6 | 8 | 6.11 | .338 | 1.52 | 10.7 | 3.1 | 5.7 | 101.2 | 120 | 73 | 69 | 15 | 35 | 64 | 3 | 0 | 0 | 2 | 6 | 1 | 1 | 4.73 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 48 | 0 | 3 | 5 | 4.27 | .344 | 1.56 | 8.8 | 5.2 | 8.4 | 59.0 | 58 | 29 | 28 | 6 | 34 | 55 | 0 | 22 | 1 | 0 | 0 | 1 | 0 | 4.24 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 49 | 0 | 4 | 3 | 5.23 | .319 | 1.39 | 8.8 | 3.7 | 9.8 | 53.1 | 52 | 36 | 31 | 12 | 22 | 58 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.06 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 40 | 0 | 3 | 2 | 5.01 | .324 | 1.41 | 8.2 | 4.7 | 9.2 | 46.2 | 42 | 27 | 26 | 10 | 24 | 47 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 5.41 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 37 | 0 | 4 | 0 | 4.24 | .317 | 1.35 | 8.6 | 3.5 | 8.5 | 51.0 | 49 | 26 | 24 | 5 | 20 | 48 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.69 |