| SP | Skubal, T.Skubal, Tarik $$ >> | 28 | 2025 | L | 100 | 18 | 18 | 5 | 9 | 4.68 | .290 | 1.18 | 8.3 | 2.4 | 10.2 | 117.1 | 108 | 61 | 61 | 14 | 31 | 133 | 0 | 0 | 0 | 0 | 9 | 5 | 1 | 3.21 |
| SP | Crochet, G.Crochet, Garrett $ >> | 26 | 2025 | L | 89 | 18 | 18 | 7 | 7 | 5.90 | .319 | 1.38 | 10.1 | 2.3 | 10.2 | 116.0 | 130 | 78 | 76 | 19 | 30 | 131 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 3.72 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 82 | 16 | 16 | 8 | 4 | 5.04 | .342 | 1.49 | 10.4 | 3.1 | 9.1 | 105.1 | 121 | 61 | 59 | 6 | 36 | 106 | 2 | 0 | 0 | 1 | 8 | 7 | 3 | 2.95 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 68 | 16 | 16 | 7 | 3 | 4.66 | .308 | 1.29 | 9.5 | 2.3 | 10.3 | 92.2 | 97 | 49 | 48 | 20 | 23 | 105 | 1 | 0 | 0 | 0 | 7 | 4 | 1 | 4.42 |
| SP | Castillo, L.Castillo, Luis † >> | 32 | 2025 | R | 67 | 17 | 16 | 8 | 2 | 3.68 | .324 | 1.43 | 10.7 | 2.2 | 6.7 | 95.1 | 113 | 39 | 39 | 12 | 23 | 71 | 0 | 0 | 0 | 0 | 10 | 1 | 1 | 3.91 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 82 | 49 | 0 | 4 | 1 | 5.95 | .336 | 1.48 | 8.2 | 5.1 | 10.6 | 56.0 | 51 | 39 | 37 | 5 | 32 | 66 | 0 | 1 | 3 | 0 | 0 | 2 | 3 | 3.63 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 45 | 0 | 4 | 0 | 2.98 | .310 | 1.34 | 9.0 | 3.2 | 7.3 | 48.1 | 48 | 17 | 16 | 7 | 17 | 39 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 4.33 |
| CL | Miller, M.Miller, Mason >> | 26 | 2025 | R | 98 | 39 | 0 | 1 | 7 | 4.40 | .308 | 1.31 | 8.4 | 3.4 | 10.4 | 45.0 | 42 | 22 | 22 | 4 | 17 | 52 | 0 | 18 | 5 | 0 | 0 | 1 | 0 | 3.04 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 74 | 42 | 0 | 1 | 2 | 2.22 | .266 | 1.07 | 6.0 | 3.8 | 9.4 | 48.2 | 32 | 12 | 12 | 5 | 20 | 50 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 3.58 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 67 | 36 | 0 | 3 | 1 | 2.79 | .280 | 1.17 | 8.8 | 1.7 | 6.2 | 42.0 | 41 | 14 | 13 | 3 | 8 | 29 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.12 |