| SP | Verlander, J.Verlander, Justin $ >> | 36 | 2019 | R | 99 | 19 | 19 | 10 | 7 | 3.84 | .286 | 1.19 | 7.6 | 3.2 | 8.8 | 117.1 | 99 | 55 | 50 | 9 | 41 | 114 | 1 | 0 | 0 | 0 | 11 | 1 | 1 | 3.13 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 18 | 18 | 6 | 8 | 4.19 | .324 | 1.41 | 8.8 | 3.8 | 8.6 | 116.0 | 114 | 59 | 54 | 15 | 49 | 111 | 0 | 0 | 0 | 0 | 10 | 4 | 5 | 4.14 |
| SP | Marichal, J.Marichal, Juan † >> | 29 | 1966 | R | 77 | 19 | 17 | 11 | 6 | 3.46 | .264 | 1.08 | 8.1 | 1.6 | 5.9 | 132.2 | 119 | 51 | 51 | 16 | 24 | 87 | 8 | 0 | 1 | 2 | 9 | 0 | 3 | 3.80 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 47 | 0 | 2 | 1 | 3.58 | .311 | 1.33 | 7.2 | 4.9 | 7.9 | 50.1 | 40 | 20 | 20 | 4 | 27 | 44 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 3.96 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 52 | 0 | 0 | 0 | 4.50 | .345 | 1.58 | 6.2 | 8.1 | 13.5 | 38.0 | 26 | 19 | 19 | 5 | 34 | 57 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.39 |
| RP | Hochevar, L.Hochevar, Luke † >> | 30 | 2013 | R | 78 | 33 | 0 | 4 | 1 | 1.84 | .237 | 0.89 | 5.5 | 2.5 | 7.6 | 44.0 | 27 | 9 | 9 | 2 | 12 | 37 | 0 | 7 | 1 | 0 | 0 | 2 | 0 | 2.86 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 17 | 0 | 2 | 1 | 1.89 | .269 | 1.05 | 7.6 | 1.9 | 7.6 | 19.0 | 16 | 5 | 4 | 1 | 4 | 16 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 2.79 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 14 | 0 | 2 | 1 | 1.47 | .247 | 0.98 | 6.5 | 2.5 | 9.0 | 18.1 | 13 | 3 | 3 | 0 | 5 | 18 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 1.83 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 11 | 0 | 0 | 0 | 6.17 | .340 | 1.54 | 8.2 | 6.5 | 8.2 | 11.2 | 10 | 8 | 8 | 1 | 8 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.55 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 13.5 | 2.0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 14 | 0 | 3 | 0 | 3.45 | .299 | 1.28 | 8.4 | 3.6 | 8.4 | 15.2 | 14 | 6 | 6 | 2 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.07 |