| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 33 | 33 | 14 | 14 | 3.70 | .272 | 1.10 | 7.8 | 2.2 | 4.7 | 241.0 | 208 | 103 | 99 | 16 | 58 | 125 | 8 | 0 | 0 | 2 | 19 | 4 | 3 | 3.60 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 32 | 32 | 14 | 16 | 4.35 | .317 | 1.37 | 9.0 | 3.4 | 4.9 | 233.2 | 234 | 131 | 113 | 27 | 87 | 126 | 16 | 0 | 0 | 1 | 12 | 4 | 3 | 4.60 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 31 | 31 | 9 | 19 | 6.24 | .350 | 1.59 | 11.0 | 3.3 | 4.0 | 189.0 | 231 | 147 | 131 | 34 | 70 | 85 | 7 | 0 | 0 | 1 | 10 | 4 | 5 | 5.61 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 31 | 30 | 12 | 11 | 4.95 | .326 | 1.42 | 9.8 | 3.0 | 5.4 | 211.0 | 230 | 132 | 116 | 23 | 70 | 127 | 9 | 0 | 0 | 0 | 14 | 6 | 3 | 4.29 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 73 | 0 | 4 | 0 | 3.87 | .278 | 1.14 | 7.6 | 2.7 | 9.4 | 95.1 | 80 | 42 | 41 | 11 | 29 | 99 | 0 | 10 | 2 | 0 | 0 | 1 | 0 | 3.37 |
| RP | Papelbon, J.Papelbon, Jonathan # >> | 27 | 2007 | R | 92 | 56 | 0 | 3 | 4 | 5.63 | .315 | 1.36 | 8.9 | 3.5 | 10.2 | 70.1 | 69 | 44 | 44 | 10 | 27 | 79 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.80 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 32 | 0 | 1 | 3 | 7.94 | .393 | 1.85 | 11.4 | 5.3 | 8.7 | 34.0 | 43 | 33 | 30 | 8 | 20 | 33 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 6.15 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 32 | 0 | 3 | 0 | 2.16 | .286 | 1.20 | 5.7 | 5.2 | 7.9 | 33.1 | 21 | 8 | 8 | 3 | 19 | 29 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.15 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 61 | 41 | 0 | 1 | 1 | 4.18 | .293 | 1.24 | 7.1 | 4.2 | 5.6 | 60.1 | 47 | 29 | 28 | 8 | 28 | 37 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.90 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 12 | 0 | 1 | 3 | 7.40 | .361 | 1.65 | 12.2 | 3.2 | 5.4 | 20.2 | 27 | 18 | 17 | 3 | 7 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.95 |