| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 19 | 19 | 8 | 10 | 3.27 | .263 | 1.06 | 8.1 | 1.5 | 9.6 | 143.0 | 128 | 59 | 52 | 13 | 24 | 153 | 7 | 0 | 0 | 1 | 14 | 1 | 3 | 2.57 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 18 | 18 | 7 | 8 | 4.53 | .301 | 1.24 | 9.1 | 2.1 | 5.6 | 131.0 | 132 | 76 | 66 | 12 | 30 | 82 | 1 | 0 | 0 | 1 | 9 | 7 | 2 | 3.79 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 17 | 17 | 4 | 6 | 6.85 | .372 | 1.77 | 11.6 | 4.3 | 8.3 | 89.1 | 115 | 82 | 68 | 15 | 43 | 82 | 1 | 0 | 0 | 0 | 4 | 1 | 3 | 4.83 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 46 | 0 | 2 | 5 | 6.70 | .387 | 1.85 | 13.0 | 3.9 | 10.1 | 49.2 | 71 | 46 | 37 | 12 | 21 | 55 | 0 | 2 | 4 | 0 | 0 | 2 | 2 | 5.35 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 38 | 0 | 2 | 2 | 2.06 | .238 | 0.92 | 5.4 | 2.8 | 9.4 | 48.0 | 29 | 14 | 11 | 3 | 15 | 50 | 0 | 7 | 1 | 0 | 0 | 1 | 1 | 2.73 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 25 | 0 | 2 | 1 | 1.93 | .282 | 1.18 | 6.1 | 4.5 | 9.6 | 28.0 | 19 | 7 | 6 | 1 | 14 | 30 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 2.82 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 17 | 0 | 1 | 0 | 3.98 | .307 | 1.33 | 8.6 | 3.6 | 12.2 | 20.1 | 19 | 9 | 9 | 3 | 8 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.45 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 19 | 0 | 1 | 1 | 3.05 | .225 | 0.82 | 4.5 | 3.2 | 10.8 | 20.2 | 10 | 7 | 7 | 4 | 7 | 24 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.40 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 3 | 0 | 0 | 1 | 5.06 | .407 | 2.06 | 10.8 | 9.0 | 12.6 | 5.1 | 6 | 3 | 3 | 0 | 5 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.20 |